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Senior Director, Global IT Infrastructure & Service Operations

Job in South San Francisco, San Mateo County, California, 94083, USA
Listing for: structuretx
Full Time position
Listed on 2026-08-02
Job specializations:
  • IT/Tech
    IT Infrastructure, Cloud Computing: Infrastructure & Operations
Salary/Wage Range or Industry Benchmark: 253000 - 319000 USD Yearly USD 253000.00 319000.00 YEAR
Job Description & How to Apply Below

About Us:

Structure Therapeutics develops life‑changing medicines for patients using advanced structure‑based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‑stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top‑tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

We are seeking a strategic, hands‑on Senior Director, Global IT Infrastructure & Service Operations to lead worldwide IT infrastructure strategy and deliver reliable, high‑performance end‑user experiences across the US and China. This leadership role owns the end‑to‑end delivery of secure, scalable, and resilient infrastructure—including Microsoft Cloud services, collaboration platforms, and business‑critical systems—while directly leading the global Service Management / Helpdesk function.

You will drive operational excellence, streamline ticket management, champion end‑user training and support, and build a high‑performing global team that enables seamless productivity and innovation. Reporting to Vice President of IT, you will blend visionary architecture planning with day‑to‑day execution, vendor/MSP oversight, and continuous improvement to support rapid business growth in a multi‑region environment.

Job Responsibilities:

Global Infrastructure & Cloud Strategy (AI‑Enablement Focus)
  • Own the end‑to‑end architecture, design, modernization, and operations of global IT infrastructure (cloud platforms, high‑performance networking, compute clusters, storage, endpoints, identity, and collaboration tools) across US, China.
  • Lead Microsoft‑centric services (Microsoft 365, Intune, endpoint management, collaboration platforms) as the primary end‑user and productivity backbone, while ensuring infrastructure supports integration and heavy usage of diverse AI tools.
  • Build and maintain scalable, high‑throughput infrastructure foundations suitable for AI workloads: GPU/accelerated compute resources, large‑scale storage for datasets/models, low‑latency networking, and elastic scaling capabilities — across cloud providers as needed to optimize performance, cost, and compliance.
  • Drive simplification, standardization, technical debt reduction, disaster recovery, business continuity, and regulatory compliance (e.g., GxP/SOX if applicable) in a multi‑region setup.
Global Networking & Connectivity
  • Architect and manage the global network stack, ensuring secure, reliable, high‑performance connectivity across all sites and regions.
  • Oversee enterprise networking solutions (e.g., Fortinet/Cisco/Meraki switches, routers, wireless, SD‑WAN capabilities) for seamless hybrid/multi‑site operations.
  • Implement and maintain secure global connectivity solutions, including International Private Leased Circuits (IPLC), MPLS, or equivalent dedicated links for low‑latency, high‑bandwidth data transfer between US, China.
  • Lead Zero Trust Network Access (ZTNA) and secure web gateway implementations (e.g., Zscaler platform) to enable always‑on, secure remote/hybrid access with granular policy enforcement, threat protection, and data loss prevention.
  • Manage always‑on VPN solutions and secure remote access frameworks to support global workforce mobility while maintaining compliance and performance SLAs.
Security Infrastructure & Operations
  • Own the enterprise security stack in close collaboration with infosec leadership, including next‑generation firewalls (e.g., Fortinet, Palo Alto, or Cisco equivalents),…
Position Requirements
10+ Years work experience
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