Senior Director, Information Technology South San Francisco, CA

The Position

As our Senior Director, Information Technology,you’llreport to the SVP, Technology & Business Operations and lead the strategy, operations, security, and evolution of Maze’s enterprise technology environment.

This is a role for a leader who can balance strategy with hands‑on execution.

You’lllead our internal IT team while evolving our operating model with Managed Service Providers (MSPs) and strategic partners to deliver reliable, secure, and responsive technology services.

As Maze advances its clinical programs and prepares for increasingly complex global development,you’llensure our technology environment can scale with the business. You’ll partner across Clinical, Quality, Regulatory, Finance, Legal, HR, Research, Informatics, and other functions to modernize how we work, strengthen cybersecurity, improve the employee technology experience, and help expand the use of AI and automation across the company.

This position is based in our South San Francisco headquarters and requires onsite presence a minimum of three days per week.

• Develop and execute Maze’s enterprise IT strategy and roadmap aligned with business growth, clinical development, security, and compliance needs.
• Lead the delivery of enterprise IT services, including Microsoft 365, identity and access management, endpoints, networking, cloud services, business applications, and end‑user support.
• Modernize the employee technology experience, including onboarding, access provisioning, support, and authentication.
• Establish meaningful service levels, operational metrics, and performance expectations that drive accountability and continuous improvement.
• Own IT financial planning and investment prioritization, balancing business value, risk, employee experience, scalability, and cost.

• Lead Maze’s transition to an effective MSP‑enabled operating model across end‑user support and infrastructure.
• Establish clear roles, accountability, service expectations, and ways of working between internal IT leaders, MSPs, and strategic technology partners.
• Lead, coach, and develop Maze’s IT leadership team, building trust, collaboration, and shared accountability across IT Operations, Infrastructure, and Helpdesk.
• Manage vendor performance, service quality, escalation, cost, and continuous improvement while ensuring Mazeretainsownership of technology strategy, security, risk, and business outcomes.
• Create a service‑oriented culture where internal teams and external partners operate as one IT organization focused on delivering an exceptional employee experience.
• Remain close enough to the technology and operations toidentifyissues, remove roadblocks, and guide the team effectively.

• Develop and execute Maze’s cybersecurity strategy and multi‑year roadmap, maturing capabilities across identity, endpoints, networks, SaaS applications, data protection, monitoring, third‑party risk, and incident response.
• Improve Maze’s ability to proactively identify, assess, and mitigate cybersecurity risks.
• Maintain strong disaster recovery, business continuity, and incident response capabilities.
• Support SOX, GDPR, audits, access controls, and applicable
  
  GxPand computer system validation requirements.

• Build trusted partnerships across Clinical Development, Quality, Regulatory, Finance, Legal, HR, Research,Drug Discovery, and Technical Operations.
• Establish a proactive IT business‑partnership model thatanticipatesfunctional needs,identifies opportunities to improve how teams work, and translates those needs into the technology roadmap.
• Support the technology needs of global clinical…