Senior Clinical Operations Asset Director; Immunology, Neurology, Ophthalmology, and CVRM

The Position

We advance science so that we all have more time with the people we love.

Early Clinical Development (ECD) Clinical Operations partners across Research & Development to advance innovative medicines from first-in-human studies through proof-of-concept. Our team provides strategic operational leadership that shapes development plans, drives execution excellence, and enables high-quality, efficient clinical trials. We work across disease areas, functions, and geographies to deliver scalable operational solutions, build organizational capabilities, and accelerate the development of transformative therapies for patients.

As a Senior Clinical Operations Asset Director, you will provide strategic leadership across one or more development assets in Immunology, Neurology, Ophthalmology, and/or CVRM (Cardiovascular, Renal & Metabolism) while helping shape disease area strategy and the future of Clinical Operations. You will collaborate with senior cross-functional leaders, influence portfolio decisions, and build capabilities that improve execution across the organization.

In this role, you will:

• Lead the operational strategy for one or more early development assets, ensuring alignment with clinical development objectives, portfolio priorities, and enterprise strategy.
• Serve as the Clinical Operations representative on cross-functional asset teams, influencing study design, operational planning, feasibility, timelines, and execution strategies.
• Drive operational excellence by developing scalable processes, innovative solutions, and best practices that improve delivery, quality, cost, and speed across programs.
• Partner with Therapeutic Area leadership and key stakeholders to identify risks, guide strategic decisions, and ensure consistent execution across the disease area.
• Build and strengthen Clinical Operations capabilities through organizational leadership, workforce planning, talent development, and continuous improvement initiatives.
• Lead and develop high-performing teams, providing coaching, mentorship, and performance leadership while fostering an inclusive, collaborative culture.
• Represent Clinical Operations in governance, enterprise initiatives, and external collaborations, influencing strategic priorities across Roche and advancing new ways of working.

You are a strategic clinical development leader who thrives in complex, matrixed environments and enjoys building both innovative clinical programs and high-performing organizations.

You bring:

• Bachelor's degree in a scientific or healthcare discipline (advanced degree such as MS or PhD preferred).
• 14+ years of clinical development or related pharmaceutical/biotechnology experience, including significant experience in early clinical development.
• Demonstrated experience leading complex global clinical programs, assets, or portfolios.
• Experience managing and developing high-performing teams, including direct people leadership within matrix organizations.
• Deep understanding of global clinical development, ICH-GCP, regulatory requirements, and operational best practices.
• Proven ability to influence senior leaders and drive alignment across highly matrixed, cross-functional organizations without direct authority.
• Strong strategic thinking and business acumen with the ability to balance scientific, operational, financial, and organizational priorities.
• Experience leading organizational change, implementing scalable operational improvements, and driving innovation, including digital or AI-enabled solutions.
• Exceptional communication, collaboration, and stakeholder management skills with the ability to build trusted partnerships across functions and geographies.
• A leadership style grounded in integrity, inclusion, accountability, and continuous learning, with a passion for developing people and delivering meaningful outcomes for patients.

Onsite presence on our South San Francisco campus is expected for at least 3 days a week.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of California is $215,000 - $399,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our…