Senior Scientist , Biologics Purification Development; Mechanistic Modeling & AI​/ML

Company Description

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on X, Facebook, Instagram, You Tube, Linked In and Tik Tok.

The Biologics CMC Development team at Abb Vie has a distinguished history of advancing complex biologic therapies through all phases of development, from discovery to licensure. Our state-of-the-art facility in South San Francisco provides comprehensive CMC capabilities and a highly collaborative environment focused on innovative drug substance development. You will join a team that has enabled 20+ IND submissions and two successful BLAs.

We are seeking a highly motivated Senior Scientist I to join the Purification Development team. This individual will apply mechanistic modeling and/or advanced AI / machine learning (ML) strategies to the development, optimization, and scale-up of robust, phase-appropriate purification processes for biotherapeutic candidates. The ideal candidate will leverage historical and incoming process data to drive process understanding, forecast outcomes, and accelerate project timelines.

• Design, implement, and validate mechanistic models and/or AI/ML (e.g., for process performance prediction, process understanding, and workflow optimization) using historical and real-time data from lab scale purification development and pilot/GMP manufacturing.
• Actively seek out opportunities to optimize current platform or enhance our understanding of purification unit operations using advanced models and wet lab experiments.
• Contribute to or drive mechanistic modeling efforts for chromatography and/or membrane separations, supporting process control and troubleshooting.
• Execute wet lab validation experiments with detailed documentation practices.
• Collaborate closely with cross-functional teams to meet project deliverables and timelines.
• Analyze complex datasets, utilize advanced data visualization tools, and communicate data-driven recommendations to technical teams.
• Proactively monitor relevant scientific literature and integrate innovative bioprocess advances.
• Write technical publications, reports, presentations, and regulatory filings; publish research in peer-reviewed journals and present work at scientific conferences.
• Mentor junior staff and uphold best practices in documentation, safety, and GxP compliance where applicable.

• BS, MS, or PhD in Computer Science, Statistics, Applied Mathematics, Bioinformatics, Machine Learning, Computational Biology, Data Science, Chemical Engineering, Bioengineering, or a related field, with typically 10+ years (BS), 8+ years (MS), or 0+ years (PhD) of industry or research experience as either: an expert in mechanistic modeling for protein separations with some demonstrated proficiency in AI/ML approaches.
• Able to manage and organize large data sets to help interpret results using data visualization tools.
• Strong understanding of statistical analysis, process modeling, and data visualization.
• Able to independently design, execute, use and reference literature publications, and interpret laboratory experiments to answer scientific questions.
• Must be forward‑thinking and be able to lead and contribute to technical discussions and innovation.
• Able to independently learn, understand and execute novel, advanced scientific techniques related to bioprocess development.
• Has strong communication skills including verbal, written, and scientific data presentation.
• Understands biochemistry and bioprocess engineering concepts.
• Strong attention to detail; active and quick learner; able to change course quickly as needed; raises the bar and is never satisfied with the status quo; open to suggestions and embraces the ideas of others; collaborative actively builds relationships with others.
• Experienced in…