Senior Scientist, In Vivo Cardiometabolic Diseases

** Job Description
** The Cardiometabolic Disease (CMD) department at our Company’s Research Laboratories located in South San Francisco is seeking a highly innovative and rigorous Senior Scientist with a proven track record in renal and cardiovascular disease biology. The successful candidate will lead hypothesis-driven research projects from mechanistic pathway discovery and target identification to experimental design and advanced data analysis, driving the discovery pipeline for cardiovascular and renal disorders.

This role requires deep expertise in developing and characterizing in vivo animal models, integrating multi-omics approaches, and designing in vitro systems to interrogate disease mechanisms. The candidate will collaborate across cross-functional teams, mentor junior scientists, and manage complex non-clinical studies, contributing to our Company’s mission of advancing novel therapeutic targets.
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* Key Responsibilities:

*** Independently initiate and lead discovery projects to uncover and validate therapeutic targets for cardio-renal diseases
* Establish and characterize renal, cardiovascular, and metabolic animal models, utilizing functional in vivo endpoints, tissue/plasma genomics/proteomics/transcriptomics/metabolomics, and in vitro cell-based and biochemical assays
* Develop and optimize in vitro systems and cell-based functional assays for mechanism-of-action studies and compound profiling and screening
* Integrate omics data (including single-cell transcriptomics from patient-derived tissues) to inform target selection strategies
* Leverage imaging strategies (e.g., confocal fluorescence microscopy or intravital multiphoton microscopy) to investigate quantitative disease endpoints
* Spearhead collaborative projects across multidisciplinary teams and co-manage partnerships with external academic and industry collaborators
* Present impactful findings at internal and external meetings and contribute to scientific publications and technical reports
* Diligently document research activities using electronic lab notebooks; take on shared lab-based responsibilities
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* Qualifications:

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* Education:

*** Bachelor's (with 7 years), Master's (with 4 years) or Ph.D. (with 1 year) in Biology, Physiology or a related discipline and relevant experience in academic or industrial settings
** Required

Experience and Skills:

*** Extensive hands-on experience in developing and characterizing in vivo rodent models for renal (e.g. DKD, ADPKD, FSGS) and cardiovascular disease (e.g. heart failure, ASCVD), including survival surgeries (e.g., osmotic mini-pump implantation), cardiovascular phenotyping (echocardiography, hemodynamic assessments), renal phenotyping (glomerular filtration rate measurements, assess serum and urinary biomarkers), and/or metabolic cage measurements
* Experience in designing, executing, and interpreting in vitro and ex vivo experiments
* Strong record of impactful publications, oral and poster presentations at international conferences, and recognition for research excellence
* Proven ability to be a team player, lead collaborative cross-functional projects, and manage complex non-clinical studies
* Advanced skills in scientific communication, data analysis (e.g. RStudio, Graph Pad Prism, Ingenuity Pathway Analysis), statistical methods, and electronic lab documentation
* Strategic and independent thinker with a drive to innovate and initiate, own and efficiently advance projects through the discovery pipeline. Proven ability to understand disease mechanisms and solve complex problems by undertaking innovative approaches and applying state-of-the art technologies
** Preferred

Experience and Skills:

*** Proficiency in iPSC-based assays and CRISPR/Cas9 gene editing
* Demonstrated expertise in multi-omics approaches (single-cell RNA-seq, tissue/plasma proteomics) and data integration for target identification and validation#EligibleforERP
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* Required Skills:

** Accountability, Cardiovascular Diseases, Cardiovascular Surgery, Data Analysis, In Vitro Studies, In Vivo Animal Models, In Vivo Experiment, In Vivo Models, In Vivo Studies, Parasitology, Phenotyping, Survival Surgeries
** Preferred

Skills:

** Current Employees apply

Current Contingent Workers apply
** US and Puerto Rico Residents Only:
** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please  if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.  As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.  

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