Research Scientist, Mass Spectrometry

Department Summary:

The Biologics Engineering with Advanced Mass Spectrometry (BEAM) group at Amgen South San Francisco applies state-of-the-art mass spectrometry to support the discovery and development of next-generation biologics. Our scientists provide detailed analytical characterization of large molecule reagents and therapeutic candidates, enabling Amgen’s biologics programs to advance with confidence, speed, and scientific rigor.

• Independently execute standardized end-to-end LC–MS workflows (25%) for intact protein, glycan, and peptide mapping analyses, including sample preparation, instrument operation, and routine data interpretation.
• Independently maintain and operate routine mass spectrometry instrumentation (25%), including calibration, solvent management, performance monitoring, maintenance, and issue resolution.
• Characterize proteins and biologics using advanced mass spectrometry tools (25%), working with senior team members on complex structural mass spectrometry studies, analytical method development, and evaluation of new columns, reagents, and workflows.
• Communicate analytical findings, project status, and technical challenges (15%) within the BEAM group and across cross-functional teams to support coordinated project execution and delivery of tailored analytical reports.
• Ensure compliance (10%) with all Amgen safety, data integrity, and electronic lab notebook (ELN) documentation standards.

100% onsite in South San Francisco, CA.

Collaborative, fast-paced, and laboratory-focused setting requiring close interaction with cross‑functional teams.

Role includes a combination of routine laboratory execution, shared operational responsibilities, and independent analytical problem solving.

• BS/BA + 6 years, MS + 3 years, or PhD in Analytical Chemistry, Biochemistry, or a related scientific discipline with substantial hands‑on mass spectrometry experience.
• Minimum 2 years of experience building and executing LC–MS methods using Thermo Scientific mass spectrometers.
• Minimum 2 years of experience with peptide mapping workflows for PTM characterization, proteomics applications, or biopharmaceutical large molecule LC–MS analysis.
• Experience running high‑flow LC systems, supporting LC method optimization for specific analytical challenges, and independently troubleshooting and maintaining performance of LC instrumentation
• Excellent written and verbal communication skills, with a commitment to scientific accuracy, collaboration, and clear data communication.
• Strong organizational and time management skills with the ability to manage multiple concurrent projects and priorities.

• Strong expertise in protein mass spectrometry workflows and large molecule analytical characterization.
• Experience with Agilent TOF instrumentation and Bio Confirm software for large molecule analysis.
• Experience performing or supporting biophysical characterization assays, such as DSF or MALS, for analysis of proteins and protein complexes.
• Demonstrated ability to independently design and execute LC–MS experiments for intact protein, subunit, and peptide mapping analyses using Thermo Scientific systems.
• Hands‑on experience with in‑solution and in‑gel digestion workflows to confirm protein identity, determine PTM localization, and identify glycopeptides.
• Demonstrated ability to adapt to evolving project priorities and experimental challenges in a fast‑paced research environment.
• Familiarity with electronic laboratory notebooks (ELN) and industrial laboratory safety practices. Proven ability to proactively identify technical risks or experimental challenges and propose practical solutions.
• Experience contributing to shared laboratory operations, including consumable management, laboratory organization, and operational efficiency initiatives.
• Experience delivering tailored analytical reports and communicating complex scientific concepts to cross‑functional collaborators.