Scientist, Discovery

Roles and Responsibilities of the Position:

• Conceive and execute experiments for target discovery, validation, and credentialing across emerging therapeutic modalities — including, but not limited to, oligonucleotide conjugates, lipid nanoparticles, and engineered cell therapies
• Interrogate mechanism of action, biomarkers of response, and mechanisms of resistance or sensitivity for genetic medicine modalities applied to oncology
• Design and execute functional and genetic perturbation experiments to nominate and credential targets, leveraging gene editing, RNA interference, and primary or engineered cell systems as appropriate
• Analyze, interpret, and present data clearly to the team and broader organization, and contribute to cross‑functional program strategy
• Actively participate in group discussions and collaborate with colleagues across discovery, translational, and external partner functions
• Contribute to a safe, efficient, and rigorous workplace

• PhD in immunology, cancer biology, molecular biology, cell biology, biochemistry, or a related discipline, with 5+ years of lab‑based experience
• Strong understanding of oncogenic and/or immune signaling pathways, with demonstrated ability to design experiments that interrogate molecular mechanism in primary or engineered cell systems
• Hands‑on experience with gene perturbation platforms — including CRISPR‑based gene editing and RNA interference (siRNA, shRNA)
• Experience with general molecular biology techniques (PCR, cloning, Western blot)
• Highly organized, detail‑oriented, and self‑motivated, with strong presentation and documentation skills
• Excellent interpersonal and problem‑solving skills, with the ability to communicate effectively with colleagues, vendors, scientific advisors, and staff at all levels

• Experience with multi‑color flow cytometry, including panel design and analysis
• Experience designing and executing in vivo experiments, including study design, model selection, and interpretation of pharmacodynamic and efficacy endpoints
• Familiarity with in vivo gene delivery and modification approaches, including lipid nanoparticles, viral vectors (lentivirus, AAV), or related platforms
• Prior experience working with emerging therapeutic modalities such as oligonucleotide conjugates, mRNA therapeutics, or cell therapies
• Experience designing and executing functional or genetic screens, including hit triage, deconvolution, and downstream validation strategies