Principal Research Scientist, Analytical Chemistry

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About IDEAYA Biosciences: IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in‑class, targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody‑drug conjugates, or ADCs, for molecularly defined solid tumor indications.

Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized to alter the course of disease and improve clinical outcomes for patients with cancer.

Location: South San Francisco, CA.

We are seeking a talented and highly motivated individual with significant pharmaceutical industry experience to join our multidisciplinary team and help oversee all aspects of discovery analytical work. The successful candidate will work collaboratively with medicinal chemistry and related cross‑functional teams to successfully deliver drug discovery pipeline goals. This position is based in our South San Francisco headquarters and is required to be onsite four days per week in accordance with our company policy.

Reporting to:
Vice President, Medicinal Chemistry.

• Oversee small molecule analytical chemistry efforts across the IDEAYA discovery portfolio.
• Manage and execute compound purifications (including chiral SFC separations), structural elucidations, biophysical property determinations (such as solubility, logD, and pKa determinations), and stability studies.
• Manage junior analytical chemist(s) to achieve strong productivity with high quality and scientific rigor.
• Ensure existing methods are technically sound, well developed and fit‑for‑purpose.
• Troubleshoot methods and provide technical guidance across discovery programs.
• Manage installation and maintenance of lab analytical equipment.
• Perform vendor review and selection and provide oversight of all analytical work at external CROs.
• Proactively communicate with and work closely with other functions to help align analytical strategy and achieve goals.
• Help hire high‑caliber analytical chemists as needed to build and grow a world‑class analytical department.
• Stay aware of newly emerging techniques and technologies and bring new capabilities online as necessary.

• Ph.D. in analytical chemistry or related discipline with minimum of five years of drug discovery experience and demonstrated ability operating successfully within cross‑functional groups.
• Strong subject matter expertise in small molecule purification (both HPLC and SFC essential), physicochemical…