Senior Director, Small Molecule Drug Discovery in Inflammation Discovery

Career Category Scientific Job Description Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year.

Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based.

If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

What you will do Let’s do this. Let’s change the world. In this vital role you will lead early discovery inflammation research for small molecule programs at Amgen from target identification through preclinical assessment to IND and FIH. The Senior Director, Small Molecule Drug Discovery in Inflammation will provide strategic, and scientific leadership across Amgen’s Inflammation Small Molecule Research portfolio, with accountability for advancing high-impact programs from early discovery through clinical and regulatory support.

The Senior Director will define target- and portfolio-level strategies for small molecule modalities, including traditional small molecules, degraders, molecular glues, ADCs, and emerging chemistry-enabled approaches. The Senior Director will serve as a senior scientific leader within Inflammation Research, representing the function across governance forums, portfolio reviews, and strategic initiatives. The role requires deep expertise in the molecular mechanisms of immunological diseases paired with experience leading matrixed teams in areas related to small molecule drug discovery including screening, medicinal chemistry, structural biology, PKDM and translational safety.

• Through cross-functional collaboration, this Senior Director will develop integrated discovery strategies that connect target biology, molecular mechanism, and modality selection to maximize therapeutic impact for small molecule programs.
• Provide scientific and organizational leadership for inflammation programs and strategies.
• Oversee the advancement of pipeline programs through key decision points, ensuring robust biology and mechanistic insight, clear development hypotheses, and fit-for-purpose data packages.
• Represent Inflammation Research in cross-functional and governance forums and portfolio strategy discussions.
• Identify and evaluate new therapeutic opportunities including external innovation and internal pipeline expansion.
• Lead highly matrixed teams across sites and functions, fostering collaboration, accountability, scientific rigor, and delivery through organizational change.
• Mentor TA scientists in small molecule drug discovery and program leadership roles.
• Provide expert guidance to senior management on high-impact science, portfolio, and organization.
• Provide technical guidance and mentorship to scientific talent while strengthening team capabilities.
• Create a cohesive, inclusive, creative and high-performing scientific culture.
• Contribute to broader site and functional leadership initiatives, including culture, sustainability, operational excellence, and cross-functional engagement.
• Maintain strong internal and external scientific presence through publications, presentations, collaborations, and thought leadership in immunology and inflammation.
• Partner with Research and Development colleagues as needed to support clinical strategy, regulatory submissions, protocol…