Senior Principal Scientist -Bioanalytical Assay- Cell Therapy

The Position

We advance science so that we all have more time with the people we love.

The Senior Principal Scientist serves as the scientific leader for Bioanalytical Strategy in support of our Cell Therapy portfolio. In this role, the individual will define and drive the bioanalytical strategy needed to answer the critical scientific questions that enable the successful development of cell therapy products. The Senior Principal Scientist will establish integrated, fit-for-purpose strategies that generate the evidence needed to inform development, regulatory, and portfolio decisions across multiple programs.

As the cell therapy bioanalytical subject matter expert, this role will partner across Bioanalytical Sciences, Research, Translational Medicine, Clinical Development, CMC, Regulatory, and Computational Sciences to identify and prioritize the key scientific questions required to advance cell therapy programs. These include characterizing the in vivo fate of therapeutic cells, including cellular expansion, persistence, trafficking, biodistribution, phenotypic persistence and evolution, and immunogenicity, and evaluating how these attributes relate to efficacy, durability, and safety.

Working collaboratively across the organization, the leader will establish harmonized bioanalytical strategies that enable consistent evaluation across programs, accelerate scientific learning, leverage shared assays and data, and maximize portfolio-wide impact. This individual will shape scientific direction across multiple programs, establish best practices across the Cell Therapy portfolio, and represent Bioanalytical Sciences as a scientific leader within cross-functional teams.

Opportunity:

As an integral member of our dynamic team, you will:

• Define and drive the bioanalytical strategy supporting the Cell Therapy portfolio, establishing integrated, fit-for-purpose data strategies that generate the evidence needed to answer key scientific questions and inform development and portfolio decisions.
• Identify, prioritize, and continually evolve the key scientific questions required to characterize the in vivo fate of therapeutic cells, including cellular expansion, persistence, trafficking, biodistribution, phenotypic evolution and persistence, and immunogenicity, and evaluate how these attributes relate to efficacy, durability, and safety.
• Partnering with the Bioanalytical Sciences project leads to developing integrated bioanalytical strategies that generate the evidence needed to address critical scientific questions while ensuring analytical approaches remain fit-for-purpose throughout development.
• Build strategic partnerships across Research, Translational Medicine, Development Sciences, Clinical, CMC, Regulatory, Computational Sciences, and platform organizations to align scientific priorities and integrate bioanalytical strategies across the portfolio.
• Harmonize scientific approaches, leverage shared assays and bioanalytical data, and establish portfolio-wide best practices for evaluating cell therapy products across programs and development stages.
• Drive consistency and scientific excellence in bioanalytical strategy by identifying opportunities to standardize approaches, enable cross-program data interpretation, maximize portfolio learning, and accelerate the development of current and future cell therapy modalities.
• Integrate bioanalytical, translational, clinical, computational, and manufacturing insights to support molecule progression, development strategy, regulatory planning, and portfolio decision-making.
• Translate emerging questions in cell therapy development into clear bioanalytical evidence-generation strategies, including recommendations for analytical approaches, data integration, and interpretation across programs.
• Evaluate emerging scientific and technological advances and guide the incorporation of innovative bioanalytical approaches that address evolving questions across the Cell Therapy portfolio.
• Represent Bioanalytical Sciences on cross-functional governance teams, scientific review committees, portfolio forums, and external scientific collaborations.
• Serve as a recognized scientific resource for…