Postdoctoral Fellow-Discovery Protein Science

Postdoctoral Fellow-Discovery Protein Science

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

The integrative Protein Generation and Protein Design groups within Discovery Protein Science are seeking a highly motivated and creative scientist to develop impactful platforms toward advancing new therapeutic hypotheses. In this vital role, you will apply interdisciplinary approaches to develop methodologies for autoantigen profiling, with implications for target identification and biomarker discovery.

This is a 4-year fellowship within Amgen's Research & Development Postdoc Program, which is dedicated to training the next generation of biomedical scientists. This is an onsite laboratory position at our South San Francisco site. To support your research, you will have access to state-of-the art molecular biology, protein design, protein expression, protein biochemistry, and flow cytometry capabilities.

Responsibilities:

• Construct and validate protein libraries for autoantigen profiling
• Apply generated libraries to profile the binding of complex mixtures of antibodies
• Interact and collaborate with scientists cross-functionally, gaining broad exposure to the process of drug discovery
• Make novel discoveries that contribute to the broader field, disseminating scientific contributions through impactful publications and conference presentations

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Postdoctoral Fellow we seek is a professional with these qualifications.

Basic qualifications

• PhD at the time of appointment in molecular biology, chemical biology, biochemistry, or related life sciences disciplines

Preferred qualifications

• Demonstration of independent design, execution, and interpretation of experiments and results, as exemplified by a solid publication record with first-author publication(s)
• Proven experience in sequence and structure-based construct design to improve protein expression and high-efficiency cloning methods
• Experience with protein library construction, mammalian cell culture, flow cytometry, and NGS analysis workflows is a plus
• Excellent critical thinking, organizational, and communication skills
• Passion to learn and work collaboratively within a large team of scientists with diverse technical and cultural backgrounds

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is $100,000.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Amgen does not have an Final date to receive applications for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.