Scientist 3 – Translational Medicine – OMNI – Inflammatory Bowel Disease

The Opportunity

As a Scientist 3 in Translational Medicine OMNI, you will play a pivotal role in advancing our research in Inflammatory Bowel Disease (IBD). Positioned at the intersection of wet-lab experimentation and data science, you will collaborate with interdisciplinary teams to identify and validate novel therapeutic targets and biomarkers. In this high-impact role, you will apply human-relevant models and high-dimensional omics data to drive biomarker discovery and enable reverse translation, directly influencing clinical development strategies.

• Design and perform experimental studies using patient-derived human biospecimens (e.g., intestinal tissue biopsies, blood, stool) to unravel disease mechanisms in IBD.

• Establish and execute complex human-relevant model systems (including intestinal organoids, primary immune cell co-cultures, and air-liquid interface systems) to investigate pathway biology and therapeutic mechanisms of action.

• Develop, qualify, and execute custom assays (e.g., multiplex immunoassays, ELISA, flow cytometry, histology) to generate pharmacodynamic and disease-relevant readouts.

• Analyze and integrate high-dimensional datasets (scRNA-seq, CITE-seq, spatial transcriptomics, proteomics) using R or Python to discover biomarkers and support patient stratification.

• Support clinical biomarker research strategies by translating laboratory findings into actionable insights for cross-functional clinical development programs.

• Evaluate and implement emerging technologies and experimental platforms to continually advance our translational research capabilities in IBD.

• Collaborate closely with cross-functional partners across Research, Bioanalytical Sciences, Biostatistics, Computational Sciences, and Clinical Development to present findings and drive project goals.

• Education:
  
  PhD with post-doctoral experience in Immunology, Cell/Molecular Biology, Mucosal Biology, Biochemistry, or a related life sciences discipline, backed by a strong peer-reviewed publication record.

• Experience:
  
  Minimum of 3 years of hands-on experience in immunology or mucosal biology, ideally focused on Inflammatory Bowel Disease (IBD) research.

• Technical Expert:
  Proven technical expertise in benchtop techniques (flow cytometry, multiplex immunoassays, ELISA, RT-qPCR, histology) and single-cell workflows (scRNA-seq, CITE-seq).

• Analytical:
  Proficient in coding with R or Python for analyzing, visualizing, and interpreting large-scale preclinical and clinical omics datasets.

• Independent Scientist:
  Demonstrated ability to independently design, execute, and troubleshoot complex scientific studies while managing multiple priorities in a collaborative environment.

• Direct hands-on experience with primary cell isolation from human intestinal tissue.

• Advanced expertise with complex disease models, including 3D organoid cultures, co-culture systems, air-liquid interface organoids, or microphysiological systems (gut-on-a-chip).

• Experience using computational tools to directly analyze high-dimensional single-cell, spatial transcriptomics, or proteomics data beyond standard bench generation.

• Demonstrated track record of effective cross-functional collaboration within a matrixed, interdisciplinary research environment.

• Willingness to work in an open, highly collaborative environment with flexibility for global business hours as required.