Scientist, Pharmacokinetics

Job Title

The Drug Metabolism and Pharmacokinetics (DMPK) group within the PDMB function is seeking a highly motivated, collaborative scientist to support mass spectrometry-based immunogenicity assessment.

The successful candidate will contribute to the execution of MHC-Associated Peptide Proteomics (MAPPs) studies and related LC-MS workflows used to characterize antigen presentation and support biologics, conjugates and peptides programs.

The ideal candidate will primarily perform laboratory-based activities and be responsible for executing cell-based and immunoaffinity workflows, preparing samples for LC-MS analysis, maintaining laboratory instrumentation, and generating high-quality experimental data. The candidate will work in a multidisciplinary environment alongside scientists in immunology, bioanalysis, and mass spectrometry and will have opportunities to present findings at departmental meetings and contribute to scientific publications and presentations.

In this exciting role, your primary activities will include:

• Execute MAPPs (MHC-associated peptide proteomics) experiments to support immunogenicity risk assessment of therapeutic candidates.
• Maintain and expand human cell cultures, including routine cell maintenance, cell counting, viability assessment, and preparation of samples for downstream analysis.
• Perform immunoaffinity enrichment workflows, including antibody-based capture, antigen processing, and sample preparation for LC-MS analysis.
• Operate, maintain, and troubleshoot LC-MS instrumentation, including Orbitrap-based high-resolution mass spectrometry platforms.
• Generate, document, and review high-quality experimental data following established laboratory procedures and data integrity standards.
• Support optimization of sample preparation workflows and laboratory automation initiatives to improve efficiency and reproducibility.
• Maintain laboratory equipment, consumables, and records while ensuring compliance with safety and quality requirements.

Education:

• Bachelor's (with 3+ years) or Master's in Biochemistry, Analytical Chemistry, Immunology, Cell Biology, Molecular Biology, Pharmaceutical Sciences or a related scientific discipline with relevant laboratory experience

Required

Experience and Skills:

• Hands-on experience with fundamental laboratory techniques, including pipetting, sample preparation, buffer preparation, and laboratory documentation
• Understanding of immunoaffinity (IA) or antibody-based enrichment techniques
• Experience operating or supporting LC-MS workflows and bioanalytical instrumentation
• Experience maintaining mammalian cell cultures and performing routine cell-based laboratory procedures
• Familiarity with high-resolution mass spectrometry (e.g., Orbitrap) platforms and associated data acquisition software
• Ability to collect, document, and analyze experimental data
• Understanding of research principles and experimental methodology
• Demonstrated attention to detail, organization, and commitment to generating high-quality scientific data

Preferred

Experience and Skills:

• Knowledge of MAPPs (MHC-associated peptide proteomics) workflows and immunogenicity assessment strategies
• Familiarity with Thermo Scientific Orbitrap mass spectrometry platforms, including Eclipse Orbitrap systems
• Experience with proteomics sample preparation, peptide characterization, and mass spectrometry-based proteomics workflows
• Experience with automated liquid handling systems, robotics, or laboratory automation platforms
• Experience using proteomics data analysis software such as Proteome Discoverer, Max Quant, Genedata Expressionist, Peaks, or related tools
• Experience working in a pharmaceutical, biotechnology, or research-driven environment

Antibodies, Biochemistry, Cell Culture Techniques, Laboratory Documentation, Liquid Chromatography-Mass Spectrometry (LC-MS), Mammalian Cell Culture, Mass Spectrometry (MS), Pharmacokinetics, Pipetting, Sample Preparations

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US and Puerto Rico Residents Only:

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