Scientist 3, Cell Therapy - T Cell Biology

The Position

The Cell Therapy department within Genentech Research and Early Development (gRED) is seeking a motivated scientist to help develop novel cell therapies for patients with intractable diseases.

We are looking for a highly collaborative, detail-oriented scientist with deep expertise in T cell biology and a strong foundation in primary T cell culture, multiparameter flow cytometry and immune cell engineering. The successful candidate will bring scientific rigor, creativity and a resourceful approach to solving complex biological and technical problems.

This individual will work across diverse scientific and functional teams to advance Genentech’s cell therapy pipeline. The position reports to a Principal Scientist and will contribute to the scientific direction, collaborative culture and continued growth of the Cell Therapy department.

• Culture and engineer primary T cells and other relevant cell types.
• Develop and apply multiparameter flow cytometry assays to characterize T cell identity, differentiation state, activation, function, and fitness.
• Evaluate engineered T cells using appropriate phenotypic and functional assays, including proliferation, cytokine production, cytotoxicity and persistence-related measurements.
• Analyze complex datasets, draw incisive conclusions and use results to guide subsequent experimental strategy.
• Collaborate effectively with research, translational, computational, process development and other partner groups across and outside gRED.
• Maintain comprehensive and accurate experimental records using electronic laboratory systems.
• Communicate findings clearly through written reports, data packages and presentations to project teams and other stakeholders.
• Contribute to scientific and strategic planning for the Cell Therapy department and Genentech’s broader cell therapy pipeline.

• PhD, MD, DVM or equivalent degree with at least 3 years of relevant experience
• Extensive hands‑on experience with primary T cell isolation, activation, culture, expansion and phenotypic characterization.
• Deep knowledge of T cell biology, including development, differentiation, effector function, exhaustion, memory and survival.
• Advanced experience in multiparameter flow cytometry, including panel design, selection of appropriate controls, assay optimization, data analysis and biological interpretation.
• Experience engineering primary immune cells using viral and non‑viral gene delivery methods.
• Experience developing and executing cell‑based functional assays relevant to T cell biology or cell therapy.
• Demonstrated ability to design rigorous experiments, troubleshoot complex technical problems and interpret multidimensional datasets.
• A record of scientific, technical or process improvement contributions in a relevant field, demonstrated through publications, patents, regulatory submissions or meaningful contributions to therapeutic programs.
• Strong organizational and communication skills, including the ability to document, present and discuss results with multidisciplinary audiences.
• A collaborative mindset and demonstrated ability to advance shared objectives across project teams.
• A strong work ethic grounded in scientific curiosity, rigor, attention to detail and a commitment to high‑quality research.

• Knowledge of human T cell development, lineage specification or thymic biology.
• Familiarity with high‑dimensional or spectral flow cytometry and associated analysis tools.
• Experience developing CAR‑T, TCR‑T or other engineered T cell therapies.
• Knowledge of CAR design, vector biology, T cell manufacturing or critical quality attributes relevant to engineered T‑cell products.
• Experience with CRISPR‑based or other genome‑engineering technologies in primary T cells.
• Experience culturing and engineering human induced pluripotent stem cells (iPSCs).
• Experience differentiating iPSCs or hematopoietic progenitors toward immune or T‑cell lineages.
• Experience working within multidisciplinary cell therapy discovery or development teams.
• Familiarity with in vivo models of liquid and solid tumors

Relocation benefits are available for this posting.

The expected salary range…