Inflammation Research - In Vivo Pharmacology Senior Scientist
Listed on 2026-08-20
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Research/Development
Research Scientist, Immunology Research, Drug Discovery, Pharmaceutical Science/ Research
Inflammation Research
- In Vivo Pharmacology Senior Scientist
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Inflammation Research
- In Vivo Pharmacology Senior Scientist
What you will do
The Department of Inflammation Research is seeking a dedicated, driven and independent Senior Scientist to join the In Vivo Pharmacology (IVP) group as part of a fast-paced, integrated and interactive research group exploring therapeutics for Inflammation, Autoimmune, and Rare Disease programs. The successful candidate will be responsible for designing and executing experiments exploring and understanding the pharmacology of drug targets; generating, communicating pharmacology and preclinical data to support the progression of research projects, and providing technical expertise to therapeutic area scientists.
This role has the potential for managing up to one report initially, contribution to project teams, collaboration with therapeutic area scientists and teams at multiple Amgen sites.
Who are you
- PhD degree in immunology, biology, pharmacology or relative disciplines with strong knowledge of in vivo Pharmacology and experience working with PK-PD relationships.
- Post-doc or industry experience will be a plus.
- Strong expertise in hands‑on expertise in animal (rodent) handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy) essential.
- Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models. Experience with colitis, lupus, arthritis, hepatitis, and immune modulation (TLR, DTH, Immunization) models preferred. Experience in derm, rheumatoid, and respiratory disease models is preferred.
- Hands‑on experience with ex vivo / in vitro cellular, and biochemical assay techniques (i.e. ELISA, MSD, WB, quantitative RT-PCR, tissue protein extraction) is essential.
- Significant experience with multicolor flow cytometry, including Spectral flow approaches and knowledge of and experience working with immune cell populations is essential.
- Experience working in a collaborative team-oriented environment and working on project teams leading in vivo contributions is essential.
- Attention to detail, excellent organizational, time management, and communication skills, accurate & timely record keeping and data analysis are essential.
- Demonstrated track record of independent critical thinking and scientific achievement.
- Computer literacy, especially proficiency with Graph Pad Prism, Excel, PowerPoint and Word.
Key Responsibilities
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- Design, conduct and lead in vivo preclinical model studies and ex vivo analysis independently in collaboration with Inflammation scientists and collaborators.
- Design, execute and data analysis of cutting‑edge research and in vivo pharmacology experiments contributing to Amgen’s Inflammation TA research pipeline.
- Manage a scientist/associate scientist level direct report
- Utilize in vivo pharmacology and animal models to validate and accelerate molecules through the research pipeline.
- Inform, collaborate, and communicate in vivo planning and results with therapeutic area (TA) scientists to align with project goals.
- Responsibility for and oversight…
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