Senior Scientist, In Vitro Cardiometabolic Disease

** Job Description*
* Our company's South San Francisco research laboratory is seeking a highly motivated, energetic, and skilled  
** Senior Scientist (R3)
** with a strong  _in-vitro_  background in biology, biochemistry, or pharmacology to join the Cardio-Metabolic Disease (CMD) department.  This is a hands-on, lab-facing role, providing  
** _in-vitro_*
* ** expertise
* * to metabolic and endocrine disease-related exploratory and pipeline programs, with flexible skill sets to meet our current and future needs.

The individual will independently design, execute, analyze, and interpret complex  _in-vitro_  studies to support target identification, validation, and therapeutic development. The successful candidate will also possess a strong sense of intellectual curiosity to expand their technical expertise at the bench, as well as effective written and interpersonal communication skills to explain complex experiments and biological concepts to a broader scientific team.

*
* Key Responsibilities:

*
* + Design, perform, troubleshoot, document, analyze, and interpret  _in-vitro_  experiments, with minimal supervision, to support and/or lead multiple exploratory activities and pipeline projects.

+ Develop and validate complex  _in-vitro_  models and establish sets of  _in-vitro_  assays, suitable for the mechanistic investigation of potential targets, as well as evaluation of therapeutic candidates, for metabolic and endocrine diseases.

+ Work independently in executing tightly controlled experiments and presenting high-quality data to multi-disciplinary project teams.

+ Identify and implement opportunities to reduce timelines, improve throughput, and increase operational efficiency.

+ Stay current with emerging scientific and technological advances relevant to metabolic and endocrine diseases.

+ Contribute to the internal and external scientific visibility of the Obesity and Metabolism Group through presentations, publications, and scientific engagement.

*
* QUALIFICATIONS:

*
* *
* Education:

*
* + Bachelor's (with 7+ years), or Master's (with 4+ years) in Biology, Biochemistry, Pharmacology, or related discipline with the indicated years of relevant industry experience.

** Required

Experience and Skills:

*
* + Experience in more than one of the following areas:  target identification, target validation, quantitative assay development, metabolic diseases, neuro-endocrine diseases.

+ Expertise in working with more than one type of disease-relevant human primary cell or cell line (e.g. adipocytes, hepatocytes, myocytes, osteocytes, endocrine cells) in both routine and complex assay systems.

+ Demonstrated ability to manage multiple projects and competing priorities while maintaining scientific rigor and attention to detail.

+ Professional level of communication of data, with skills in collaboration and cross-functional partnership.

+ Deep scientific curiosity and analytical mindset with a drive to understand biology and mechanism of action, while aligning their work with project goals and business needs.

** Preferred

Experience and Skills:

*
* + Experience working with GPCR targets, and developing quantitative, 96-well and 384-well plate cell-based assays.

+ Mastered several standard biochemistry and molecular biology techniques (e.g. mRNA isolation, qRT-PCR, ELISA, HTRF, AphaLISA, Our company, western-blotting).

+ Expertise in developing metabolic disease-relevant  _in-vitro_  phenotypic and functional assays (e.g. calcium flux, cAMP/IP1 accumulation, beta-arrestin, receptor dimerization, glucose uptake, lipid uptake, lipolysis, Seahorse, high-content imaging through cell-painting or immunofluorescence staining).

+ Vast experience in titrating various modes of target modulation (e.g. small molecules, peptides, antibodies, antibody-peptide conjugates, siRNA, viral-vectors).

+ Demonstrated ability to employ AI agents and LLMs for hypothesis generation, literature synthesis, experimental design, complex data analysis, or competitive intelligence.

EligibleforERP

*
* Required Skills:

*
* Assay Development, Biochemical Assays, Cell Culture Techniques, Drug Target Identification, High Content Screening, Immunoassays, Immunology, Metabolic…