Associate Director, Bioanalytical Sciences

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history.

This role is based at Alector’s headquarters in South San Francisco, CA. Regular onsite presence is essential given the combination of hands-on laboratory work, scientific leadership, and close collaboration with multidisciplinary teams

As an Associate Director, Bioanalytical Sciences you will provide strategic and hands-on scientific leadership for bioanalytical activities across Alector’s nonclinical and clinical programs. This role combines portfolio-level bioanalytical strategy with direct laboratory engagement and independent assay development.

Leverage yourdeepexpertisein ligand-binding assaysfor pharmacokinetics, and immunogenicityassessmentsacrossarangeof biologial matrices,comfortablymovebetween thehand s-onlaboratoryworkandscientific andpeople lea dership.

The role enc ompasses bioanalytical strategy, independent assay develop ment, optimiz ation, and troubleshooting at the bench, CRO oversi ght, data int er pretationand operational decision-making for the group rather than simply coordinating or delegating activities.

• Define and drive bioanalyticalstrategyacross programs! Develop fit-for-purpose Pharmacokinetic, Pharmacodynamic, immunogenicity, and biomarker strategies that address key scientific questions,anticipate assay needs,identify risks early, and supporttimelynonclinical and clinical program decisions.

• Lead assay development and stay hands-on in the laboratory! Independently design, develop,optimize, troubleshoot, and qualify ligand-binding assays using both ELISA and MSD platforms, with proven experience developing assays for antibodies, including PK, ADA, and neutralizing antibody assays.

• Translate bioanalytical data into clear scientific decisions! Interpret complex results across programs, communicate findings and risks to multidisciplinary teams, and author or critically review high-quality bioanalytical plans, technical reports, study reports, and related scientific documentation.

• Partner across functions and proactively align expectations! Work with Research, Toxicology, and Clinical Development to align Bioanalytical Sciences priorities, timelines, and capacity with program needs, protecting the team from conflicting demands while continuously improving processes, SOPs, and documentation standards.

• Lead and develop the team! Build a culture of scientific rigor, accountability, and respect where team members feel comfortable raising questions and challenging assumptions; mentor scientists at all experience levels in a way that removes barriers rather than adding to their workload.

• Build strong external bioanalytical partnerships! Apply a strong understanding of GLPand bioanalytical guidelines whenparticipatingin the evaluation and selection of CROs for nonclinical and clinical assay validation and sample analysis; develop robust human bioanalytical assays for transfer to CROs and provide scientific oversight of method transfer, validation, sample analysis, troubleshooting, deviations, data quality, timelines, and final study reports.
  
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