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Oligonucleotide Scientist II

Job in South San Francisco, San Mateo County, California, 94083, USA
Listing for: Merck & Co.
Full Time position
Listed on 2026-09-12
Job specializations:
  • Research/Development
    Research Scientist, Drug Discovery, Pharmaceutical Science/ Research
Salary/Wage Range or Industry Benchmark: 96000 - 138000 USD Yearly USD 96000.00 138000.00 YEAR
Job Description & How to Apply Below

Job Title
:
Oligonucleotide Scientist II

Working Model
:
Fully on-site, South San Francisco, CA 94080

Working Days
:
Monday to Friday

Duration
: 12 months contract (with possible extension)

Terms
:
Contract W2

Interview Format
:
One Round (30 minutes) - Local candidates should join the interviews on site, candidates outside of the immediate area may join virtually

SKILLS
  • Hands-on expertise in oligonucleotide therapeutics discovery, synthesis, and nucleic acid chemistry to support RNAi drug discovery programs.
  • BS/MS degree in Organic Chemistry or a related scientific discipline.
  • Hands-on experience with automated oligonucleotide synthesizers, oligonucleotide synthesis, purification, and characterization techniques.
  • Strong experience with analytical platforms including HPLC and Mass Spectrometry for oligonucleotide purification, characterization, and impurity profiling.
  • Knowledge of RNAi therapeutics and nucleic acid therapeutic modalities within pharmaceutical or biotechnology research environments.
  • Preferred experience in large molecule drug discovery, oligonucleotide delivery technologies, or bioconjugation approaches.

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