Senior Scientist - Experimental Protein Design Target Discovery

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnesses drives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Lets do this. Lets change the world. In this vital role you will build and lead high-throughput platforms for binder generation, translating computational protein designs into experimentally validated mini binders and antibodies across diverse pre-discovery targets. A key focus of this role is the production, experimental validation, and characterization of computationally designed de novo binders. You will play a central role in creating scalable binder libraries for multiplexed phenotypic screening, developing multispecific tool molecules to interrogate novel biology and providing tool reagents for early-stage target characterization.

By integrating computational design with rapid experimental validation, you will advance high-throughput binder discovery strategies and drive innovative approaches to probe emerging targets and accelerate early-stage therapeutic discovery.

• Translate computational protein designs into experimentally testable mini binders and antibodies across multiple targets in parallel.
• Lead high-throughput workflows for binder expression, purification, and characterization, including development of cellular assays for binder target evaluation.
• Partner with molecular biology teams to establish construct generation and binder library production workflows, enabling both individual binder characterization and scalable pooled library screening.
• Develop strategies to format de novo binders into appropriate modalities (e.g., multispecifics) to enable testing of biological hypotheses.
• Analyze and interpret experimental data to guide iterative design-build-test cycles.

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a highly motivated researcher with these qualifications.

• Doctorate degree PhD
• OR PharmD
• OR MD [and relevant post-doc experience on Protein Engineering]
• OR
• Masters degree and 3 years of Protein Engineering experience
• OR
• Bachelors degree and 5 years of Protein Engineering experience

• Ph.D. in Biochemistry, Protein Engineering, Bioengineering, Structural Biology, or a related field plus relevant postdoctoral experience.
• Demonstrated experience in the expression, purification, and biochemical or biophysical characterization of engineered proteins, such as antibodies, mini binders, or other designed scaffolds in a high-throughput or library-based manner.
  
  Experience with different expression hosts (cell-free expression,
  
  E. coli, and mammalian) is a plus.
• Experience in binder hit…