Inflammation Research - In Vivo Pharmacology Scientist

Career Category Research Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year.

Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based.

If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

What you will do The Department of Inflammation Research is seeking a dedicated, driven and independent Senior Scientist to join the In Vivo Pharmacology (IVP) group as part of a fast-paced, integrated and interactive research group exploring therapeutics for Inflammation, Autoimmune, and Rare Disease programs. The successful candidate will be responsible for designing and executing experiments exploring and understanding the pharmacology of drug targets;

generating, communicating pharmacology and preclinical data to support the progression of research projects, and providing technical expertise to therapeutic area scientists. This role has the potential for managing up to one report initially, contribution to project teams, collaboration with therapeutic area scientists and teams at multiple Amgen sites.

• PhD degree in immunology, biology, pharmacology or relative disciplines. Post-doc or industry experience will be a plus.
• Strong expertise in hands‑on expertise in animal (rodent) handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy) essential.
• Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models. Experience with colitis, lupus, arthritis, immune modulation (TLR, DTH, Immunization), and respiratory models preferred.
• Hands‑on experience with ex vivo / in vitro cellular, and biochemical assay techniques (i.e. ELISA, MSD, WB, quantitative RT-PCR, tissue protein extraction) is essential.
• Significant experience with multicolor flow cytometry, including Spectral flow approaches and knowledge of and experience working with immune cell populations is essential.
• Experience working in a collaborative team‑oriented environment and working on project teams leading in vivo contributions is essential.
• Attention to detail, excellent organizational, time management, and communication skills, accurate & timely record keeping and data analysis are essential.
• Demonstrated track record of independent critical thinking and scientific achievement.
• Computer literacy, especially proficiency with Graph Pad Prism, Excel, PowerPoint and Word.

• Design, conduct and lead in vivo preclinical model studies and ex vivo analysis independently in collaboration with Inflammation scientists and collaborators.
• Design, execute and data analysis of cutting‑edge research and in vivo pharmacology experiments contributing to Amgen’s Inflammation TA research pipeline.
• Utilize in vivo pharmacology and animal models to validate and…