Director, Biostatistics

ABOUT THE COMPANY

Marea Therapeutics is a clinical-stage biotechnology company based in South San Francisco with a growing pipeline of first-in-class therapies to address genetically validated cardioendocrine disease targets. Our therapies have the potential to serve as transformative treatment options for significant patient populations living with cardioendocrine diseases.

The company’s lead program, MAR
001, is being developed for the treatment of severe hypertriglyceridemia (sHTG), a condition characterized by very high triglyceride levels and elevated risk of acute pancreatitis. Preclinical models with MAR
001 demonstrated reduction in triglycerides, remnant cholesterol and ectopic fat, and improved insulin sensitivity. MAR
001 has demonstrated strong and a differentiated profile in patients and is approaching Phase 3 development. Our second clinical asset, MAR
002, is a monoclonal antibody targeting excess growth hormone produced by the pituitary gland in the rare hormonal disorder, acromegaly. MAR
002 has potential to become best-in-disease and is quickly progressing into Phase 2/3 clinical development. We also have a third asset that is swiftly advancing through research discovery, with DC nomination expected this year.

At Marea, we believe in the power of collaboration and the importance of leading by example. We are a tight-knit team that values the contributions of every member, from interns to senior leaders. Our environment is dynamic, with each day presenting new challenges and opportunities for growth. Every role is “Hands-On”,and the successful candidate will be able to work alongside team members, regardless of level, to understand challenges and drive results.

Reporting to the Vice President, Biostatistics, the Director/Senior Director, Statistics will provide strategic and operational leadership across Marea Therapeutics’ clinical development programs. This position will lead statistical activities across multiple studies, serve as the Biostatistics representative on clinical study teams, and oversee external CRO partners to ensure scientific rigor, regulatory compliance, and timely execution. The role combines hands-on statistical expertise with leadership to advance Marea’s clinical pipeline.

This is a full-time, South San Francisco-based position with the expectation of working on-site at least three days per week.

• Statistical planning for, and interpretation of, preclinical and clinical programs
• Work cross-functionally to find strategic and creative problem‑solving for statistical approaches in studies, including researching new statistical methods to support program needs that align with regulatory and industry standards
• Ensure the statistical strategy aligns with the company’s business objectives which includes understanding the company’s goals when it comes to the regulatory submissions, scientific publications, and other corporate needs
• Collaborate with thought leaders and experts in the field to ensure that statistical methods and findings are in line with best practices and the latest scientific and statistical advancements
• Define, institute, and oversee best practices with regard to planning, execution, handling, and interpretation of scientific and clinical results to ensure high quality and compliant data handling and interpretation
• Ensure strong data handling and infrastructure, including ongoing evaluation and implementation of systems and vendors
• Identify, engage, and manage key biometrics vendors, consultants, and thought leaders (e.g., in statistics, programming, and data management)
• Provide statistical oversight and support global regulatory strategy, planning, submissions, and interactions
• Anticipate, identify, and assist in…