Scientist - Rare Disease Biology

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnesses drives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Lets do this. Lets change the world. In this vital role you will contribute to the discovery and advancement of innovative therapies for rare diseases as a core member of multidisciplinary, disease-focused research teams. You will apply experimental and data-driven approaches to investigate disease mechanisms, evaluate novel therapeutic targets, and generate insights that inform scientific and portfolio decisions.

This role offers the opportunity to work at the intersection of autoimmune disease biology, fibro-inflammatory mechanisms, tissue remodeling, human disease data, and emerging technologies within a highly collaborative and scientifically rigorous environment.

• Design, execute, analyze, and interpret in vitro and ex vivo studies to investigate disease mechanisms and evaluate therapeutic hypotheses.
• Generate high-quality, reproducible experimental data to support target identification, validation, and progression of rare disease research programs.
• Investigate biological mechanisms relevant to Thyroid Eye Disease (TED), including immune dysregulation, fibroblast activation, inflammatory signaling, extracellular matrix regulation, and tissue remodeling.
• Integrate experimental findings with scientific literature, human genetics, clinical observations, and multi-omic datasets to develop mechanistic insights and inform scientific decision-making.
• Develop and implement innovative experimental approaches that enhance scientific rigor, efficiency, and translational relevance.
• Collaborate closely with disease biologists, computational scientists, translational researchers, and other partner functions within multidisciplinary research teams.
• Contribute data-driven insights and recommendations to scientific discussions, target reviews, program strategy, and portfolio evaluations.
• Build productive relationships with internal and external collaborators, including academic investigators, foundations, CROs, and scientific experts, as appropriate.
• Communicate scientific findings, interpretations, and recommendations effectively to project teams, governance forums, and departmental audiences.
• Maintain accurate experimental documentation and contribute to organizational knowledge sharing.
• Foster a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.

We are all different, yet we all use our unique contributions to serve patients. The Scientist we seek is a researcher with these qualifications.

Doctorate degree

OR

Masters degree and 2 years of relevant scientific research experience

OR

Bachelors degree and 4 years of relevant scientific research experience

• Expertise in one or more areas relevant to fibroblast biology, stromal cell biology, tissue remodeling, fibrosis, extracellular matrix biology, inflammation, or fibro-inflammatory disease.
• Experience investigating cellular and molecular mechanisms that drive tissue inflammation, remodeling, and pathological structural changes.
• Demonstrated expertise in designing and executing cell-based, molecular, and biochemical assays to interrogate complex disease biology and therapeutic hypotheses.
• Hands-on experience with primary human cells, fibroblast systems, tissue-derived cultures, organoids, or other advanced in vitro/ex vivo disease models.
• Strong…