Senior Scientist, Respiratory Biology; Discovery Research

The Senior Scientist will join the Respiratory Biology Discovery group and contribute to target identification, target validation, translational biology, and mechanism-of-action studies supporting early discovery programs in chronic lung diseases, including COPD, bronchiectasis, asthma, pulmonary fibrosis, and inflammatory airway diseases.

The successful candidate will leverage human-relevant in vitro, ex vivo, and translational experimental systems, with a particular emphasis on primary airway and alveolar epithelial biology, epithelial-stromal and immune-stromal interactions, tissue remodeling, fibrosis, regeneration, and biomarker discovery. The Senior Scientist will generate high-quality mechanistic datasets that inform target prioritization and program decisions and will collaborate closely within multidisciplinary discovery and translational teams.

The salary range for this role is $ - $

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at

• Design, execute, and interpret in vitro and ex vivo studies to support respiratory target discovery, validation and translational biology programs.
• Develop and apply disease‑relevant experimental systems, including primary airway epithelial cultures, air‑liquid interface (ALI) models, organoid systems, precision-cut lung slices (PCLS), and co‑culture platforms.
• Generate mechanistic datasets to investigate epithelial dysfunction, tissue remodeling, fibrosis, immune responses, and regenerative biology in chronic lung diseases.
• Apply imaging techniques, including immunohistochemistry (IHC), immunofluorescence (IF), and high‑content imaging, with image‑based analysis to interrogate disease‑relevant biology.
• Perform and interpret flow cytometry/FACS‑based immune and cell phenotyping.
• Support translational biomarker discovery and validation using patient‑derived samples and multiplex biomarker platforms (Meso Scale Discovery, Luminex, Olink, AlphaLISA).
• Integrate cellular, molecular, imaging, and biomarker datasets to inform project decisions and translational strategies.
• Generate reproducible, high-quality data packages and communicate findings through presentations, technical reports, and cross‑functional discussions.
• Collaborate closely across biology, pharmacology, DMPK, and translational and clinical teams within a matrixed discovery environment.

• Bachelor's (with 7+ years), Master's (with 4+ years) or Ph.D. biology, immunology, pharmacology, physiology, pulmonary biology or related discipline and relevant experience

• Demonstrated expertise in respiratory biology and human primary cell culture systems, including airway and/or alveolar epithelial models
• Experience developing and applying disease-relevant in vitro and ex vivo systems such as ALI cultures, organoids, co‑culture models, or precision‑cut lung slices
• Strong hands‑on experience in molecular and cellular biology techniques
• Experience with flow cytometry/FACS, imaging‑based approaches (IHC, IF, ICC,…