Scientist, Research Scientist

Scientist

Career Category Research

Job Description Join Amgen's Mission of Serving Patients At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission- to serve patients living with serious illnesses- drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas
-Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let's do this. Let's change the world.

Amgen is seeking a Scientist to join the Pathology Laboratory within the Translational Safety & Risk Sciences (TSRS) Department in South San Francisco, California. The Scientist will develop and apply tissue-based assays, including multiplex assays and digital image analysis, to support target expression studies, preclinical model development, pharmacodynamics, efficacy, and biomarker discovery.

• Develop, optimize, validate, and standardize histopathology assays using FFPE samples, including single-plex and multiplex immunohistochemistry (IHC) and in situ hybridization (ISH) in colorimetric and immunofluorescent formats.
• Use imaging modalities and digital pathology tools to generate, analyze, and interpret tissue-based data for target qualification, pharmacodynamic and efficacy assessments, and biomarker development.
• Collaborate with pathologists, research investigators, and translational teams to deliver high-quality data supporting mechanism-of-action studies, in vivo model development, and toxicity assessments across therapeutic areas.
• Maintain clear, complete documentation and communicate results through laboratory information systems, databases, and team presentations.

• Doctorate degree OR Master's degree and 2+ years of relevant research and industry experience OR Bachelor's degree and 4 years of relevant research and industry experience.

• PhD or master's degree in cell biology, molecular biology, or related discipline.
• Two or more years of molecular pathology experience, preferably in an industry setting.
• Demonstrated expertise in pathology-based methods, including IHC, multiplex IHC, ISH and immunofluorescence imaging.
• Experience with digital pathology and image analysis, preferably using HALO and/or Visiopharm.
• Experience with automated staining platforms, such as Ventana, Leica Bond, or IntelliPATH, is preferred.
• Ability to manage multiple projects and priorities simultaneously.
• Excellent written and verbal communication skills.

Experience analyzing pathology imaging data, including H&E, IHC, multiplex immunofluorescence, and/or spatial transcriptomics.

Familiarity with whole-slide imaging and digital pathology platforms, such as HALO or Visiopharm, is preferred.

Understanding of machine-learning methods for image segmentation, classification, detection, and representation learning.

Strong communication, organizational, and collaboration skills in multidisciplinary scientific environments.

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that…