Scientific Associate Director, Human Disease Biology, Inflammation Research

Career Category Scientific Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year.

Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based.

If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

What you will do Let’s do this. Let’s change the world. In this vital role you will work at the intersection of disease biology, multi-omic profiling, computational analysis, and drug discovery, generating insights that advance therapeutic opportunities in respiratory, dermatologic, and/or rheumatologic diseases. The successful candidate will combine deep expertise in human disease biology with experience translating discoveries into therapeutic hypotheses and drug discovery programs.

They will serve as a scientific leader who integrates data across human genetics, transcriptomics, proteomics, spatial biology, and single-cell technologies to identify disease mechanisms, patient subsets, biomarkers, and novel therapeutic opportunities.

Key Responsibilities:

• Develop and execute a disease-focused discovery strategy leveraging multi-omic and human data to deepen mechanistic understanding of respiratory, dermatologic, or rheumatologic diseases.
• Continuous adoption of technology, AI/computation and innovation to improve efficiency and quality of work.
• Integration of systems immunology, multi-omics, AI-enabled biology, and human disease research to bring unique insights and innovative approaches to Amgen's discovery efforts.
• Lead cross-functional scientific initiatives that integrate human genetics, single-cell biology, spatial biology, proteomics, and computational analyses to identify and validate first/best-in-class therapeutic targets, patient segments and biomarker strategies.
• Drive generation and interpretation of multimodal datasets and translate findings into actionable hypotheses for target discovery and program prioritization/advancement.
• Partner closely with computational biology, translational sciences, human genetics, pathology, and disease-area biology teams to build integrated disease models and prioritize therapeutic opportunities.
• Serve as a scientific leader for disease-focused discovery efforts and provide expertise in human tissue biology, disease pathogenesis, and emerging technologies.
• Design and oversee internal and external collaborations with academic investigators, clinical researchers, consortia, and technology partners.
• Contribute to advancement of programs through target validation, indication selection, biomarker identification, and patient stratification strategies.
• Mentor scientists and foster rigorous, collaborative, and innovative scientific practices across project teams.
• Leads multiple cross-functional projects and scientific initiatives focused on disease…