Senior Principal Research Scientist, Protein Sciences

Senior Principal Research Scientist, Protein Sciences page is loaded## Senior Principal Research Scientist, Protein Sciences locations:
South San Francisco HQtime type:
Full time posted on:
Posted Todayjob requisition
-014# Non-Solicitation Policy and Notice to Agencies and Recruiters:
** IDEAYA's Non-Solicitation Policy strictly prohibits agencies and recruiters from any contact and communication with IDEAYA employees, managers, and leaders to submit unsolicited candidate resumes and/or to solicit business partnerships**. Submission of unsolicited candidate resumes by agencies or recruiters with or without a contract in place with IDEAYA Biosciences Inc. will not create any implied obligation. Failure to comply with this policy will result in disqualification from current and future business opportunities with IDEAYA Biosciences.

All recruiting and talent agency decisions are strictly managed by the internal IDEAYA Human Resources function. All communication by external agencies and recruiters must be directed to  We ask that you only email your interest once.

Job Summary About IDEAYA Biosciences:

IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications.

Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer.

When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person  are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward.

For more information, please see  South San Francisco, CA.

Position Summary:

We are seeking an accomplished and highly collaborative Senior Principal Research Scientist to make significant hands-on contributions to our Protein Sciences function while supervising and developing a small team of research associates and PhD-level scientists. This role is intended for an experienced laboratory scientist who enjoys solving challenging protein-production problems, supporting multiple drug-discovery programs, and coordinating internal and external scientific work.

The successful candidate will bring deep expertise in recombinant protein expression, purification, and characterization, including extensive experience with bacterial and insect-cell expression systems. This individual will directly contribute to the delivery of high-quality proteins and protein complexes for biochemical, biophysical, structural, and screening applications across a diverse portfolio of drug-discovery programs.

This opportunity is particularly well suited to an established career scientist who wants to remain actively engaged at the bench while expanding their impact through technical problem-solving, supervision and development of scientists, CRO coordination, and cross-functional collaboration.

This position is based in our South San Francisco headquarter offices and required to be onsite four days per week per our company policy.

Reporting to:
Vice President, Lead Discovery

Job Description
** What you'll do:
*** Contribute actively in the laboratory while coordinating the day-to-day work and priorities of the Protein Sciences team in alignment with drug-discovery program needs.
* Develop and execute protein-expression and purification strategies for challenging proteins and protein complexes using bacterial, insect-cell, and other appropriate expression systems.
* Perform and oversee construct design, expression testing and optimization, protein purification, characterization, and troubleshooting, particularly for challenging proteins and protein complexes.
* Ensure delivery of…