Scientist II

Cytokineticsis a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.

We are seeking a motivated, hands-on Scientist I/II with both in vivo and in vitro research experience, including work in iPSC-derived cardiomyocytes and other primary cell systems, engineered tissues, and animal disease models. The ideal candidate is a rigorous, detail-oriented investigator who thrives in a hands-on role and contributes to compound efficacy characterization through preclinical drug development within a highly collaborative, multidisciplinary environment.

The level of the role (Scientist I or Scientist II) will be determined based on the candidate’s experience, demonstrated independence, and degree of project and target ownership.

• Perform hands-on rodent work (mouse and rat) - handling, dosing, tissue collection, and disease model support in compliance with IACUC guidelines.
• Isolate primary cells from tissues and perform ex vivo experiments (e.g. Langendorff/perfused heart, measures of contractility).
• Perform molecular and biochemical assays (Western blot, qPCR, immunostaining/IF, ELISA, enzyme-based) to quantify markers of disease biology and target engagement.
• Culture and run functional experiments on iPSC-derived cardiomyocytes, primary cardiomyocytes, other cell types, and engineered heart tissues (EHTs) as needed.
• Independently develop, optimize, and troubleshoot cell-based and molecular assays, including for early-stage or novel targets.

• Ph.D. in Biology, Physiology, Pharmacology, or a related scientific discipline (or equivalent experience).
• Scientist I: generally 0–2 years of experience, including postdoctoral training; a B.S./M.S. with substantial relevant experience and demonstrated independent scientific contribution may be considered.
• Scientist II: generally 2–5 years of experience, including postdoctoral training.
• Prior experience in a pharmaceutical or biotechnology setting is preferred.

• Hands-on rodent handling and dosing experience (mouse and rat), including tissue collection.
• Experience isolating primary cells from tissues and performing ex vivo tissue/organ preparations (e.g. Langendorff/perfused heart or other organ perfusions).
• Hands-on proficiency in molecular and biochemical assays (Western blotting, qPCR, immunostaining/IF, ELISA, and enzyme-based assays), and the ability to independently develop, optimize, and troubleshoot cell-based or molecular assays.
• Ability to design, execute, and interpret experiments, determine next steps, and clearly communicate data in reports and presentations; works effectively across disciplines. Independent project and target ownership are required, as is a track record of scientific achievement.

• Hands-on experience with in vivo cardiovascular measures (e.g. echocardiography, blood pressure. Invasive hemodynamics)
• Hands-on expertise in mammalian cell culture, with direct experience in iPSC-derived cardiomyocytes, primary cardiomyocytes, or other primary cells, and with EHT casting and experimentation.

• A collaborative, science-driven environment focused on impactful muscle biology and cardiovascular research.
• Opportunities to grow scientific ownership and advance your career within drug discovery and development.
• A competitive compensation and benefits package.

The expected salary range for this position based on the primary location of South San Francisco, CA is $148,500-$173,250. The base pay offered will take into account internal equity and may vary depending on the candidate's…