Senior Scientist - Experimental Protein Design Target Discovery

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas
-Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role you will build and lead high-throughput platforms for binder generation, translating computational protein designs into experimentally validated mini binders and antibodies across diverse pre-discovery targets. A key focus of this role is the production, experimental validation, and characterization of computationally designed de novo binders. You will play a central role in creating scalable binder libraries for multiplexed phenotypic screening, developing multispecific tool molecules to interrogate novel biology and providing tool reagents for early-stage target characterization.

By integrating computational design with rapid experimental validation, you will advance high-throughput binder discovery strategies and drive innovative approaches to probe emerging targets and accelerate early-stage therapeutic discovery.

Translate computational protein designs into experimentally testable mini binders and antibodies across multiple targets in parallel. Lead high-throughput workflows for binder expression, purification, and characterization, including development of cellular assays for binder-target evaluation. Partner with molecular biology teams to establish construct generation and binder library production workflows, enabling both individual binder characterization and scalable pooled library screening. Develop strategies to format de novo binders into appropriate modalities (e.g., multispecifics) to enable testing of biological hypotheses.

Analyze and interpret experimental data to guide iterative design-build-test cycles.

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc experience on Protein Engineering] OR Master’s degree and 3 years of Protein Engineering experience OR Bachelor’s degree and 5 years of Protein Engineering experience

Ph.D. in Biochemistry, Protein Engineering, Bioengineering, Structural Biology, or a related field plus relevant postdoctoral experience. Demonstrated experience in the expression, purification, and biochemical or biophysical characterization of engineered proteins, such as antibodies, mini binders, or other designed scaffolds in a high-throughput or library-based manner.

Experience with different expression hosts (cell-free expression,

E. coli, and mammalian) is a plus. Experience in binder hit validation using flow cytometry and SPR, and in developing cellular-based assays for functional…