Senior Scientist - In Vivo

Y-Trap is seeking a highly motivated and fast-moving [Senior] Scientist – In Vivo, who will be responsible for design and hands-on execution of murine in vivo experiments to advance the discovery and development of multifunctional fusion proteins.

Y-Trap is a startup in South San Francisco developing novel multi-specific therapeutics for cancer immunotherapy. While current immunotherapies aim to activate and expand T cells by blocking immune checkpoints, they do not correct the immunosuppressive & tumor-promoting phenotypes of immune cells that dominate in the tumor. Y-Trap has utilized its AI-driven engineering platform to develop a portfolio of multi-specific fusion proteins designed to counteract the determinants of these tumor-promoting immune cell phenotypes.

Y-Trap is currently advancing its lead programs into the clinic.

• Independently execute mouse tumor efficacy and PK/PD studies to evaluate the effects of immuno-modulating therapeutics.
• Manage our shared space in a contract vivarium, including ordering mice/reagents and liaising with vivarium staff.
• Perform tumor implantation, dosing, blood collection, and tissue harvests; monitor tumor growth, treatment response, and animal health.
• Collaborate with the immunology team, with opportunities to contribute to in vitro assays and immune cell characterization.

• Strong oncology in vivo expertise
  . You love being in the vivarium and are great at handling mice. You're proficient in tumor implantation, tumor measurement, drug administration (i.p., i.v.), blood collection, and necropsy.
• Detail-oriented and precise. You keep meticulous notes, a detailed schedule of activities to be completed, and record/share data cleanly and promptly.
• Self-driven and resourceful. You're excited to learn new skills when needed, with a mentality to do whatever it takes to get the job done in a small team with a lot of autonomy.
• You have several years of hands-on mouse work, regardless of where you got it (maybe in your PhD/post-doc, or maybe working in industry). You're excited to use your skills to do a lot of hands-on work for the next 1-2 years.

• Experience with surgical tumor models, including performing orthotopic tumor implantation and intrasplenic tumor cell inoculation.
• Experience working with/generating humanized mice using huPBMCs and/or huCD
  34+ HSCs.
• Experience with the adjacent in vitro parts of the job -- tumor cell line culture, tissue dissociation, PK analysis, flow cytometry.
• Experience with mouse models of inflammation or autoimmune disease.

Y-Trap is based in South San Francisco, CA and offers competitive salary, benefits, and stock options. This is not an entry-level position, but candidates of varying seniority are encouraged to apply. Seniority and compensation will be commensurate to experience.