Associate Director, Clinical Operations South San Francisco

Marea Therapeutics is a clinical‑stage biotechnology company based in South San Francisco with a growing pipeline of first‑in‑class therapies to address genetically validated cardio‑endocrine disease targets. Our therapies have the potential to complement existing therapies and serve as transformative treatment options for significant patient populations living with cardio‑endocrine diseases.

Incubated by Third Rock Ventures, Marea completed a Series B financing in June 2024 and is well funded by a syndicate of leading life science investors including Sofinnova, Forbion, Xontogeny/Perceptive Advisors, venBio, Omega Funds, Surveyor, Alpha Wave and Third Rock Ventures.

The company’s lead program, MAR
001, is a monoclonal antibody targeting ANGPTL4, a genetically validated target with potential to address the subset of patients at the highest risk of adverse cardiovascular events, despite current standard of care therapies. MAR
001 is rapidly progressing through Phase 2b clinical development. Our second clinical asset, MAR
002, is a monoclonal antibody targeting excess growth hormone produced by the pituitary gland in the rare hormonal disorder, acromegaly. MAR
002 has potential to become best‑in‑disease and is rapidly progressing through Phase 1 clinical development. We also have a third asset that is rapidly advancing through research discovery, with DC nomination expected next year.

At Marea, we believe in the power of collaboration and the importance of leading by example. We are a tight‑knit team that values the contributions of every member, from interns to senior leaders. Our environment is dynamic, with each day presenting new challenges and opportunities for growth. Every role is “Hands‑On”, and the successful candidate will be able to work alongside team members, regardless of level, to understand challenges and drive results.

The Associate Director, Clinical Operations will provide leadership and operational oversight of Clinical Operations activities to execute clinical studies in a manner that ensures milestones and company goals are met, and costs maintained within budget. This role will have program‑level accountability for timeline, budget, quality, risk management, and ensuring compliance with Good Clinical Practice (GCP).

The position will work in a cross‑functional environment with representatives from other involved functions and will oversee the activities of Clinical Research Organizations (CROs) and other vendors in the conduct and management of clinical studies. The successful candidate may eventually mentor junior staff in the set‑up, maintenance, and close‑out of clinical trials.

In this role, the Associate Director will be a key clinical operations leader supporting our MAR
002 program. MAR
002 is a first‑in‑class anti‑growth hormone receptor antibody monoclonal antibody indicated for growth hormone control (IGF‑1 normalization) in acromegaly. MAR
002 has potential to become best‑in‑disease and is rapidly progressing from phase 1 to phase 2/3 clinical development. This Associate Director position will be expected to drive execution across study start‑up, vendor oversight, and delivery of high‑quality early‑phase clinical data in a rare disease setting.

This is a full‑time, South San Francisco‑based position with the expectation of working on‑site at least three days per week.

Clinical Study Leadership

• Support program lead with setting and timely executing the development strategies for the clinical studies.
• Responsible for the strategic and operational oversight, management, execution, and delivery of the clinical studies for MAR
  002 and related clinical program activities.
• Lead the Study Management Team (SMT) for assigned clinical study.
• Resolve and/or escalate issues raised by the clinical operations team or the SMT.
• Ensure consistency between studies for assigned clinical program.

CRO and Vendor Management

• Support vendor selection, including request for proposals, leading bid defense meetings, critical review of contracts and negotiation of work orders.
• Oversee CROs and other selected vendors on a product level including setting and monitoring key…