Senior Director, Medicinal Chemistry

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About IDEAYA Biosciences: IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications.

Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients.

We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person  are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward. For more information, please see

Location:

South San Francisco, CA.

We are seeking a talented and highly motivated individual with significant pharmaceutical industry experience to join our multidisciplinary team. The successful candidate will lead a group of medicinal chemists and engage in rational structure-based drug discovery enabled by our computational and structural chemistry group. In addition, the work will include aspects of managing CRO collaborators in the preparation of target molecules and leadership of drug discovery projects.

As a member of a dynamic multi-disciplinary team, this person will collaborate with a broad group of scientists within IDEAYA as well as external collaborators. This position is based in our South San Francisco headquarter offices and required to be onsite four days per week per our company policy.

Reporting to:
Vice President, Medicinal Chemistry

Requirements:

• Ph.D. in synthetic organic chemistry with 10+ to 15+ years pharmaceutical medicinal chemistry industrial experience
• Expert understanding of medicinal chemistry concepts along with strong working knowledge of protein-ligand interactions, conformational and structural analysis to enable creative solutions to drug discovery issues. A strong track record of using structure-based design is essential.
• Experience in applying molecular modeling methods to structure-based, ligand-based, and fragment-based drug discovery
• Exceptional knowledge of ADME, physicochemical, biochemical and pharmacological principles as applied to drug discovery
• High level of creativity and productivity with strong synthetic problem-solving skills
• Proven leadership capability in cross-functional team setting, either as project team leader or co-lead
• Excellent oral and written communication skills including ability to present the rationale, data, issues and accomplishments of the team
• Ability to work closely with senior management
• Experience managing PhD level reports
• A strong record of delivering portfolio success and driving projects through to the identification of high quality small-molecule drug candidates
• Experienced in partnering closely with other functional areas including: computational chemistry, DMPK, in vivo pharmacology, CMC, etc.
• Excellent awareness of current developments in synthetic and medicinal chemistry, and ability to identify opportunities to advance the science in these fields
• Strong skills in gathering, documenting, and analyzing competitive information from sources such as patents and meetings and using this information to guide program strategy
• Significant operational experience in one of the following disciplines:
  Analytical Chemistry, Computer Aided Drug Design, Structural Biology, Formulation Sciences, in vitro and/or in vivo ADME
• Strong desire to…