Senior Director, Clinical Science

Job Summary

IDEAYA Biosciences is a precision medicine oncology company focused on developing transformative therapies for cancer. We are seeking an experienced, motivated Senior Director of Clinical Science to provide medical‑scientific expertise across multiple clinical projects. The role reports to the Senior Vice President, Early Phase Clinical Development.

South San Francisco, CA – office‑based, required to be onsite four days per week.

The Senior Director will work closely with the clinical leader to develop and implement clinical study plans, oversee protocol development, review safety data, serve on study teams, and contribute to program‑level materials. The position requires independent decision‑making, strong communication, and the ability to operate within a matrix organization.

• Write clinical‑development concepts and plans for molecules at all stages, especially early oncology development.
• Draft and revise protocol synopses, protocols, and amendments.
• Develop and review informed consent forms and adjudicate site‑specific requests.
• Partner with Clinical Operations on site selection, start‑up and communication.
• Write/update clinical sections of investigator brochures and lead the initial and annual updates.
• Review clinical/safety sections of NDAs/MAAs.
• Represent the medical (clinical) function on study teams, adding functional support from the clinical leader.
• Review and interpret safety data listings, serious adverse events and lead primary authorship of study reports and associated publications.
• Create slide decks for internal and external use.
• Train staff, CROs and site personnel on therapeutic areas, molecules and protocols.
• Participate in opinion‑leader advisory boards and therapeutic area research.
• Provide support for Health Authority interactions, responding to inspection observations, audits, updates and submissions.
• Assist the Medical Monitor for Phase 1 trials, ensuring patient safety and guidance during design, execution, and reporting.
• Lead or contribute to program‑level activities such as safety and efficacy summaries, overviews, risk‑management plans, periodic safety updates and product‑label clinical sections.
• Present study results to committees, advisory boards, scientific meetings and peer‑reviewed journals.

• Bachelor’s degree in a relevant field and strong knowledge of clinical oncology from previous experience.
• Postgraduate qualification (e.g., Master’s, MD, N.P., PharmD or PhD) preferred.
• Minimum 4 years of industry experience in oncology clinical development.
• Involvement in all stages of clinical trials from start‑up to study report.
• Experience with small‑molecule trials preferred.
• Proficiency in protocol design, interpretation and medical monitoring.
• Knowledge of adverse‑event assessment and patient safety in therapeutic trials.
• Familiarity with Good Clinical Practice.
• Excellent written and oral communication skills.
• Adaptability to a fast‑paced, changing environment.
• Background in clinical operations, regulatory affairs or biostatistics is a plus.
• Fluency in English.

• Competitive salary range: $276,000–$341,000.
• Performance‑based merit and discretionary incentive plans.
• Stock‑option awards and ESPP participation.
• Medical/dental/vision coverage (100% company‑paid for employees, 90% for dependents).
• 401(k) plan.
• Wellness programs.

IDEAYA is an equal‑opportunity employer that does not discriminate on basis of race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation or any other protected class. We provide reasonable accommodations for qualified individuals with disabilities. Contact  for assistance.

The role requires full vaccination against COVID‑19, with accommodations for medical or religious reasons.

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