Sr. Principal Scientist, Clinical Operations Immunology Lead

Job Description Translational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients. Our Clinical and Operations organization designs and executes clinical pharmacology strategies spanning first-in-human studies through proof-of-biology/proof-of-concept and into late-stage development, supporting worldwide marketing applications and lifecycle management.

In a competitive external landscape and fast-paced internal environment, the Immunology Clinical Operations Lead position provides both strategic and operational leadership across early immunology programs, ensuring timely, high-quality execution of clinical studies and clinical pharmacology strategies worldwide. The successful candidate will telescope between strategy and hands-on execution across a portfolio of diverse modalities (e.g. peptides, small molecules, biologics), and partner cross-functionally to develop the needed expertise to successfully advance programs to key inflection points in development.

This role is equivalent in level to a Senior Director position.

All candidates located within a 50-mile driving radius of the site will be required to come onsite on a hybrid schedule. Candidates outside of the 50-mile radius are expected to travel onsite on a regular monthly basis.

Take a clinical operations leadership role at the intersection of discovery and clinical development to advance novel immunology therapeutics from bench to bedside. Influence strategy, build teams, and deliver high-impact clinical programs that shape the future of patient care.

• Co-own and execute the early clinical development strategy for the immunology portfolio with the Head of TMed Immunology
• Provide comprehensive strategic planning and operational oversight for immunology clinical programs and trials to maximize operational feasibility, efficiency, and ensure consistency and quality across the portfolio
• Build global network of immunology sites and foster relationships with key investigators for Ph1b/2a patient trials to deliver on clinical program goals
• Serve as the deep subject matter expert and issue escalation point for early immunology clinical operations
• Ensure appropriate resources, competencies, and partnerships are in place to meet objectives
• Critically review strategy and clinical program documents (development plans, investigator's brochures, protocols, etc.), providing scientific and operational insight to ensure best path forward
• Partner with Business Development and Licensing to evaluate internal and external opportunities that align with portfolio strategy
• Actively participate in annual and quarterly planning cycles: identify risks, develop and execute mitigation plans, and track performance metrics and outcomes
• Ensure immunology data integrity across organization (Book of Business, CTMS, etc.)
• Build and sustain strong cross-functional relationships (country operations, clinical supplies, data management, regulatory, etc.) across departments, divisions, and geographies
• Foster the people pipeline:
  Attract, coach, mentor, and retain talent; provide performance management support; act as 'player-coach' to enrich group skillsets.
• Potential for people management.
• Represent TMed on enterprise strategic initiatives and lead continuous-improvement efforts that increase clinical efficiency and scientific impact
• Serve as a member of the TMed Clinical Operations leadership team and contribute to shaping department strategy

Degree in Life Sciences with one of the following experience combinations:

• Bachelor's degree + ≥16 years related experience
• Master's degree + ≥15 years related experience
• PhD/PharmD + ≥12 years related experience

pharmaceutical industry roles in clinical drug development, clinical trial management, clinical site monitoring/training, medical/regulatory writing, or translational science

• Experience leading clinical…