Senior Computational Biologist

Gordian Biotechnology is a therapeutics company whose mission is to cure age-related disease and wake up every morning more capable than the day before.

Traditional ex vivo screening methods have failed to produce effective treatments, as age-related diseases have complex causes that include interactions with the aged environment.

To address this problem, Gordian’s Mosaic Screening pools interventions in living animals, producing datasets with causal validation for hundreds of targets, in the living context of disease and mapped to human patients. This data lets us make the most informed choices on what new ideas for treating complex disease, and move validated targets into drug development. (more info on our website, and in our preprint).

We are running this discovery engine in successive indication areas, currently focused on cardiometabolic, to map the in vivo effects of every druggable target across every relevant organ. We then develop drugs and run clinical trials, both internally and in collaboration with multiple partners. And by pooling the data from each program, we can start to identify medicines with broad impact on the multimorbidity and decline caused by aging.

Our mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: we work as a team with deep ownership and trust, and we strive for extraordinary outcomes that force us to grow our capability.

Relying on each other begins with transparency. We set clear goals that visibly connect individuals to company objectives, empowering us to make autonomous decisions. Our communication happens out in the open, where we share mistakes, ask for help, and give and receive feedback from a perspective of helping each other grow.

Gordian is trying to accomplish something tremendously difficult, requiring people who care deeply about doing exceptional work. We take ownership of our work, ask every day how we can push our science forward faster, and challenge each other to continually raise the bar. Holding ourselves to that standard creates an environment where each of us grows into a better version of ourselves.

Doing exceptional work also means building a team that can sustain it. We keep standing meetings to a minimum so people can focus on the science, encourage open collaboration that strengthens experimental design, and connect over weekly team lunches. We also encourage people to unplug with an unlimited vacation policy. This has created an environment where our team can thrive, as evidenced by a voluntary attrition of only ~6% per year.

Gordian is at an exciting inflection point, having recently generated in vivo perturbation data spanning over 500 targets across different in vivo contexts (Obesity, Heart Failure), and are actively expanding this to Chronic Kidney Disease (CKD). This growing resource is being utilized in collaboration with external partners looking to leverage our platform to help build the most comprehensive knowledge-graph of disease-relevant, translatable therapeutics spanning these disease areas.

Your mission as a Computational Biologist at Gordian is to leverage our in vivo screens to decode how cells respond to genetic perturbation at the transcriptomic level, and translate those responses into predictions of physiologically-relevant, therapeutically-actionable outcomes in disease. Based on your work, Gordian will continue to push the frontier of extracting physiological predictions from cell states. You’ll specifically focus on cardio-renal-metabolic indications and associated tissues (heart, kidney, adipose, liver, etc.),

partnering closely with our disease-area experts and experimental teams to translate…