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Senior Principal Front End Engineer — gCS CC Data & Solutions Engineering

Job in South San Francisco, San Mateo County, California, 94083, USA
Listing for: Genentech
Full Time position
Listed on 2026-02-06
Job specializations:
  • Software Development
    Software Engineer, Front End Developer
Job Description & How to Apply Below
The Position

We advance science so that we all have more time with the people we love.

At Genentech Research & Early Development (gRED) we have initiated an exciting journey to bring together and further strengthen our computational talent and capabilities by forming a new, central organization - gRED Computational Sciences (gCS). gCS is on a mission to partner across the organization to realize the potential of data, technology and computational approaches that will revolutionize how targets and therapeutics are discovered and developed, ultimately enabling novel treatments for patients across the world.

We stand at the beginning of an exciting journey.

The Computational Catalysts group within gCS is a diverse, curious and action-driven team at the intersection of computation, engineering and science with ambition to advance our technical excellence. The focus of the team is on partnering with the informatics and scientific communities to create a computational and data ecosystem that powers scientific discovery and accelerates decision making. We aim to modernize our ability to acquire, store, link, share, find and analyze data across the organization through scalable and integrated solutions that truly make every data point count.

The Data Solutions and Engineering group within Computational Catalyst is dedicated to transforming user interactions with our systems and products, emphasizing intuitive, innovative, and effective visual interfaces that simplify user interactions and drive increased user adoption. As a senior member of our newly established front-end engineering team, the Principal Front End Engineer will be instrumental in shaping our user interface strategy and developing sophisticated front-end solutions that align with increasing development velocity and common standards for the organization while maintaining user satisfaction.

The ideal candidate will collaborate closely with cross-functional engineering teams, scientists, product managers, UX designers, and business leaders to implement front-end solutions that captivate end users and boost adoption. Our goal is to craft and deliver user-centered, accessible, and impactful experiences.

Reporting to the Senior Director of Engineering, this Principal Front End Engineer will play a pivotal role in defining and executing the front-end strategy across the Catalyst organization, refining front-end development processes, increasing development velocity, and ensuring that the user interface is a fundamental driver of product success.

The Opportunity:

  • Lead the development of the front-end engineering strategy, ensuring alignment with product goals and business priorities, while advocating for best practices and educating the team.

  • Oversee the end-to-end development process across multiple projects, ensuring robust, high-performance, and user-friendly outcomes, while providing technical mentorship and leadership to the team.

  • Conduct code reviews, optimize performance, and gather technical insights to inform engineering decisions while actively participating in projects as an experienced front-end engineer, contributing to the development of user-friendly applications by maximizing expertise in front-end technologies and UI component creation, with a central focus on the user interface.

  • Collaborate with UX designers, engineers, scientists, and cross-functional teams to deliver cohesive, impactful solutions in a dynamic environment.

  • Stay updated on industry trends, emerging technologies, and engineering best practices to continuously improve development methodologies and deliver innovative solutions.

  • Establish and maintain frameworks and standards for developing scalable and maintainable front-end applications, fostering a collaborative and efficient codebase.

Who You Are:

We are looking for an innovative and hands-on Front-End Engineering leader who thrives in a collaborative, fast-paced environment. The ideal candidate will have extensive experience in building and optimizing UI components and a deep internal knowledge of front-end frameworks. You will be someone who excels in solving sophisticated engineering challenges and leads by example,…

Position Requirements
10+ Years work experience
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