Senior Software Engineer, X-Scientist

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development.

Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

Xaira is pioneering an AI-native approach to discovering and developing the next generation of life-changing medicines. We are building predictive and agentic AI systems across drug discovery, and the X-Scientist team accelerates this mission by making AI-assisted science reliable, usable, and scalable across drug discovery workflows.

On the X-Scientist team, you will work at the intersection of AI, software engineering, and therapeutic discovery. You will collaborate closely with AI scientists, engineers, platform teams, and drug discovery experts to build systems that connect AI models, biological tools, datasets, and scientific workflows.

This role spans backend systems, APIs, tool-calling infrastructure, workflow orchestration, developer-facing SDKs and CLIs, and agentic interfaces that help scientists run analyses, inspect intermediate steps, and iterate on results.

Backend systems and APIs that connect AI models to scientific tools, datasets, and analysis workflows

Tool-calling infrastructure, CLIs, SDKs, and workflow runners that scientists and ML researchers use day-to-day

Agentic interfaces where users can run analyses, inspect intermediate steps, and iterate on results

Observability and testing for long-running workflows that call external tools and produce scientific outputs

Design reliable systems for long-running, multi-step workflows with strong testing, observability, logging, and maintainability.

Collaborate with scientific and technical teams to turn complex research workflows into usable, extensible software.

Strong Python engineering fundamentals, with clean, typed, tested, maintainable code.

Experience building at least one of the following: a production library, CLI, API, SDK, backend service, workflow system, or developer platform.

Familiarity with LLM application development, agent frameworks, tool calling, MCP-style interfaces, or orchestration systems.

Comfort working with complex systems that combine multiple components, external calls, domain-specific logic, and evolving user needs.

Good instincts for abstraction, error handling, reliability, and designing software that can grow across use cases.

Strong communication skills and ability to work in a collaborative, multidisciplinary environment.

Background or interest in computational biology, bioinformatics, protein design, single-cell genomics, biomedical AI, or adjacent domains.

Familiarity with biomedical databases or tools such as Pub Med, Uni Prot, Alpha Fold, PDB, Dep Map, or related resources.

Curiosity about biology and scientific research; you do not need a biology background, but you should be excited to learn the domain and work closely with scientists and ML researchers.

We offer a competitive compensation and benefits package, including base salary, on-target annualized cash bonus, and equity. The base pay range for this position is expected to be $189,000 - $245,000 annually; however, the base pay offered may vary depending on market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics is an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

This role is based in our South San Francisco office and requires five days per week in-office.

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As set forth in Xaira Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

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