Manager​/Senior Manager, IT Infrastructure and Operations

Role Overview & Key Functions:

Karyopharm is seeking a Manager/Senior Manager, IT Infrastructure & Operations to serve as a senior individual contributor owning the architecture, reliability, and evolution of the company’s infrastructure environment, reporting to the VP, Information Technology. This is a hands‑on role operating with a high degree of autonomy, partnering across IT, Security, and the business to design and run scalable, secure infrastructure across a mix of cloud and legacy systems in a regulated environment.

This individual will lead complex initiatives end‑to‑end, drive modernization, and improve operational maturity across cloud and on‑prem environments. Operating within a lean IT team, the role requires strong ownership, hands‑on execution, and the ability to mentor others and influence infrastructure strategy without direct people management.

• Serve as the senior technical lead for infrastructure design, architecture, and operations.
• Own and execute complex infrastructure initiatives end‑to‑end (design → build → optimize).
• Act as an escalation point for critical incidents and complex system issues.
• Lead by example through hands‑on engineering, troubleshooting, and implementation work.
• Mentor and guide engineers through technical challenges, design reviews, and best practices (without direct management responsibility).
• Collaborate with IT Business Partners to identify and align solutions that balance meeting business needs and technical complexity.

• Drive cloud‑first and hybrid infrastructure strategy, including migration from legacy systems.
• Design and implement scalable solutions across AWS/Azure, on‑prem systems, and networking layers.
• Partner with IT leadership to shape long‑term infrastructure roadmaps and technical standards.
• Evaluate emerging technologies and recommend adoption aligned with business needs.

• Design and enhance monitoring, alerting, and observability frameworks.
• Improve system reliability through proactive engineering (capacity planning, performance tuning, resilience design).
• Lead root cause analysis (RCA) and implement long‑term fixes to reduce incident recurrence.
• Optimize operational workflows, including ticket triage, escalation paths, and service ownership.
• Define and monitor KPIs, SLAs, and SLOs to ensure service health and performance.

• Partner closely with Cybersecurity to ensure infrastructure aligns with SOX, GxP, and enterprise security standards.
• Implement secure architecture patterns (identity, access, network segmentation, encryption).
• Support audit readiness through strong documentation, system configuration visibility, and asset management.
• Lead infrastructure contributions to disaster recovery (DR) and business continuity planning (BCP).

• Work across teams (Applications, Data, Security, PMO) to deliver infrastructure solutions that support business initiatives.
• Act as a trusted advisor to leadership on infrastructure capabilities, risks, and trade‑offs.
• Collaborate with vendors and partners to evaluate and implement solutions.
• Drive alignment and adoption of infrastructure standards without formal authority.

• Bachelor’s degree in Computer Science, Information Technology, or equivalent experience.
• 8–10+ years of deep, hands‑on IT infrastructure experience.
• Proven ability to operate independently and lead large technical initiatives without direct reports.
• Strong expertise in:
• Microsoft ecosystem (Windows Server, Active Directory, Azure AD, O365)
• Cloud platforms (AWS and/or Azure)
• Networking (firewalls, routing, VPNs, VLANs, subnets), specifically Fortinet
• Virtualization (VMware, Hyper‑V)
• Experience with automation (scripting, Terraform/Cloud Formation, etc.)
• Strong troubleshooting and systems thinking skills across complex environments.
• Experience working in regulated environments (SOX, GxP) preferred.
• Excellent communication skills with ability to translate technical concepts to non‑technical stakeholders.