Senior Principal Scientist, Translational Clinical Biomarkers

Job Description

We are seeking an accomplished and highly motivated Senior Principal Scientist (Sr. Director equivalent) to serve as an Immunology Biomarker Lead within Translational Clinical Biomarkers. This role provides strategic and scientific leadership in the design, execution, analysis, and communication of clinical biomarker strategies across our immune-mediated therapeutic portfolio from discovery to pivotal clinical studies.

The successful candidate will drive decision-centric biomarker strategies that connect drug mechanism, disease biology, precision medicine, pharmacodynamics, dose decisions, and clinical endpoints, directly informing program‑ and portfolio‑level decisions across the development lifecycle.

This role requires strong leadership of multi‑disciplinary team efforts through deep scientific expertise, structured decision‑making, sophisticated data analysis & interpretation, and cross‑functional collaboration, aligning stakeholders in a fast‑paced, matrixed environment.

• Lead and shape integrated biomarker strategies across discovery, early‑ and late‑stage clinical programs, ensuring clear hypotheses, fit‑for‑purpose endpoints, and explicit linkage to key development decisions, in close collaboration with cross‑functional leaders, particularly in Discovery, Late‑Stage Clinical Development and across Translational Medicine.
• Serve as the biomarker strategy lead within cross‑functional program teams and represent multi‑disciplinary teams in governance forums, ensuring biomarker strategies to address mission‑critical questions for both forward and reverse translation.
• Inform portfolio strategy by advancing biomarker‑driven insights that inform target validation, patient selection, and go/no‑go decisions.
• Translate disease biology and therapeutic mechanism of action into clinically actionable biomarker strategies addressing critical program questions, e.g. proof of biology, pharmacodynamic effects, precision medicine and surrogate endpoints for efficacy.
• Drive selection and application of innovative biomarker approaches, aligned with biological rationale and clinical utility.

• Lead biomarker sub‑teams and related working groups, including clinical, discovery, translational, regulatory, bio‑stats, and data sciences.
• Collaborate effectively across disciplines to integrate scientific perspectives into cohesive strategies.
• Provide scientific leadership to enable hypothesis‑driven, decision‑focused biomarker strategies.
• Grow and develop team members, including mentorship of direct reports and other scientists in the department.

• Champion biomarker analysis plans and provide critical scientific input to the interpretation of complex datasets to deliver scientifically rigorous and clinically meaningful conclusions.
• Clearly articulate insights to internal stakeholders, governance bodies, and external scientific audiences.
• Support external engagement, including publications, presentations, and KOL interactions, as appropriate.

NOTE:
This role is available in Rahway, NJ;
Boston/Cambridge, MA; or Upper Gwynedd, PA based on candidate preference.

• Ph.D. or M.D. with 12+ years in Immunology or related scientific discipline and relevant experience with autoimmune diseases and/or translational medicine.

• Deep expertise in immunology and immune‑mediated/inflammatory diseases, with experience in at least one of the following: gastrointestinal/mucosal inflammation, rheumatology, dermatology.
• Proven track record of driving translational strategies that inform clinical development decisions, including close cross‑functional collaboration and partnership.
• Demonstrated ability to lead highly matrixed organizations.
• Strong analytical and problem‑solving capabilities, translating complex data into clear, decision‑oriented insights.
• Excellent communication skills, including experience presenting to senior leadership and external stakeholders.
• Working knowledge of biostatistics, bioinformatics, and advanced data analytics.
• Strategic mindset with a focus on decision impact…