Scientist – Integrative Proteomics; Mass Spectrometry Platform - BIohub SF

The Chan Zuckerberg Biohub San Francisco (CZ Biohub SF) is an independent nonprofit research institute that brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine. CZ Biohub SF itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies.

We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision

- We pursue large scientific challenges that cannot be pursued in conventional environments

• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at CZ Biohub San Francisco facilitate research by scientists and clinicians at our home institutions and beyond
  
  Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.
  
  The Opportunity
  
  The Mass Spectrometry Platform at the CZ Biohub-SF is a collaborative and fast-moving research group that develops and applies cutting-edge technologies at the intersection of proteomics, metabolomics, lipidomics, and computational biology. We are especially focused on mapping molecular features of cell states across scales—from subcellular structures to single cells and whole tissues—through deep integration with imaging, sequencing, and data science platforms across the CZ Biohub Network.
  
  We are seeking a technically skilled and creative Scientist to join our Integrative Proteomics efforts. This role will center on instrument optimization and method development for increasingly sensitive and high-resolution measurements—from limited input samples to spatially complex tissues—while building the automation infrastructure needed to scale these efforts across diverse projects. The successful candidate will help drive the generation of large, multimodal molecular datasets with the depth and richness to power tomorrow’s AI-driven models of biology.
  
  The scope and pace of our work—bridging emerging technologies and interdisciplinary science—are rarely possible in traditional academic or industry settings, making this a unique opportunity for someone eager to operate at the frontier of discovery biology. It is expected that the applicant will present the outcome of their work at national / international meetings, and substantially contribute to manuscript authorship.
  
  The majority of work will be performed at the Stanford campus in Palo Alto, however this position also requires infrequent visits to the Mission Bay campus in San Francisco.
  
  This role will be based in Palo Alto, CA initially, with a planned transition to Redwood City in two years.
  
  You will
  
  - Oversee and reinforce standards of high quality and high-throughput data collection
• Guide LCMS infrastructure maintenance and optimization
• Integrate knowledge of mass spectrometry-based proteomics methodologies with dynamic cellular systems
• Coordinate research activities with collaborating laboratories within the CZ Biohub-SF and allied research institutions
• Author publications and present work in internal and public forums (e.g., conferences)
• Success will be measured by the manuscripts and public data sets that you contribute to
  
  You have
  
  Essential –
  
  - Minimum education:
  
  PhD in Analytical Chemistry, Biochemistry, Cell Biology, Immunology, Systems Biology, or related field OR an equivalent amount of hands-on experience focused in the above areas.
• Minimum years of experience: >3 years in the field, inclusive of graduate research
• 3+ years of hands-on experience with Thermo orbitrap and/or Bruker tims
  
  TOF mass spectrometers
• 3+ years of hands-on…