Research Technologist - Proteomics Core Facility; Huck Institutes

Position Overview

The Proteomics and Mass Spectrometry Core Facility within the Huck Institutes of the Life Sciences is seeking a highly qualified Research Technologist (Core Research Technologist - Advanced Professional) to join our team.

This role provides critical technical expertise across the full spectrum of proteomics and small molecule analysis, including sample preparation, instrument operation, and advanced data interpretation. The successful candidate will play a key role in supporting a diverse research community and enabling high-impact scientific discovery.

Our Core is a shared instrumentation center supporting more than 50 laboratories and over 100 researchers across multiple departments and colleges at Penn State, as well as external collaborators. We operate a cutting‑edge instrumentation suite, including:

• Thermo Orbitrap Eclipse with Vanquish Neo nano-LC
• Thermo Q Exactive with Vanquish Flex LC
• Bruker Ultrafle Xtreme MALDI TOF-TOF

• Perform hands‑on operation, troubleshooting, and routine maintenance of LC-MS (Liquid Chromatography-Mass Spectrometry) systems.
• Prepare samples for downstream mass spectrometry workflows, including proteomics and small molecule analysis.
• Conduct general wet‑lab procedures in chemistry, biochemistry, or related fields.
• Execute proteomics bioinformatics workflows, including MS data analysis, interpretation, and reporting.
• Collaborate with faculty, postdoctoral researchers, and students to design experiments and provide technical guidance.
• Deliver high‑quality results and maintain detailed documentation for facility users.

• Strong working knowledge of liquid chromatography (LC) and mass spectrometry (MS).
• Hands‑on experience operating LC-MS instrumentation.
• Excellent verbal and written communication skills.
• Ability to work independently and manage multiple projects with changing priorities.

• Proteomics or metabolomics experience.
• Small molecule analysis experience.
• Bioinformatics and MS data interpretation skills.
• Wet‑lab skills in biochemistry or molecular biology.

• Strong problem‑solving and troubleshooting abilities.
• Exceptional time management and organizational skills.
• Collaborative mindset with a customer service orientation.
• Ability to effectively support a diverse multidisciplinary user base.

This is an exciting opportunity to work in a state‑of‑the‑art core facility at a leading research institution, collaborate with a wide range of scientists, and contribute to innovative research across disciplines.

Bachelor’s Degree; 3+ years of relevant experience; or an equivalent combination of education and experience accepted. No required certifications.

The salary range for this position, including all possible grades, is $51,000.00 – $74,000.00.

Penn State provides a competitive benefits package for full‑time employees designed to support both personal and professional well‑being. In addition to comprehensive medical, dental, and vision coverage, employees enjoy robust retirement plans and substantial paid time off including holidays, vacation and sick time. Employees also receive a 75% tuition discount available to employees, spouses and children.

Penn State is an equal opportunity employer and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If you are unable to use our online application process due to an impairment or disability, please contact .