Director, Project Management Office (PMO

Position Summary

The Director, Project Management Office (PMO) is responsible for leading the PMO function for the Syracuse Bio Campus and ensuring effective portfolio governance, project execution, and cross-functional alignment across client programs and strategic internal initiatives. This role establishes and drives PMO operating standards, governance processes, performance metrics, and execution disciplines that enable visibility, predictability, and delivery excellence across the project portfolio.

As a senior leader within the site and a key member of the Global PMO network, this role translates site and business priorities into PMO strategy, governance, and execution frameworks that support operational performance, client satisfaction, and business growth. The Director serves as a strategic business partner to site leadership and a senior point of contact for clients, providing leadership across Manufacturing Operations, Development (PD, AS&T), MSAT, Quality, Supply Chain, Finance, and Business Development to drive outcomes across complex biologics programs.

The ideal candidate brings deep experience in biologics and CDMO operations, strong business and financial acumen, and demonstrated success leading project management organizations, complex technical transfer and cGMP programs, and cross-functional teams in a matrixed environment.

• Lead the PMO function for the Syracuse Bio Campus, including functional priorities, governance standards, operating mechanisms, and talent development.
• Translate site, functional, and business objectives into PMO strategies, priorities, and execution frameworks that support successful delivery of client programs and internal strategic initiatives.
• Partner with the VP, Global PMO to align site PMO objectives with global PMO strategy, governance standards, reporting expectations, and continuous improvement priorities.
• Establish and sustain PMO frameworks, processes, tools, and performance measures that improve consistency, transparency, predictability, and decision‑making across the project portfolio.
• Serve as a strategic partner to site leadership, helping to identify risks, opportunities, resource needs, and operational tradeoffs that impact project delivery and business performance.
• Influence and help shape PMO best practices across the broader global network through active partnership, knowledge sharing, and adoption of scalable standards.

• Provide leadership and oversight for the execution of Syracuse client projects and key internal initiatives, ensuring delivery against scope, timelines, financial commitments, quality requirements, and customer expectations.
• Direct portfolio governance processes, including project reviews, milestone assessments, escalation management, portfolio reporting, and decision‑support mechanisms for site and global leadership.
• Ensure risk management, issue escalation, and mitigation planning are embedded within project execution and aligned across cross‑functional stakeholders.
• Drive portfolio visibility through clear governance, KPI reporting, lessons learned, and performance reviews that support timely and effective decision‑making.
• Lead PMO engagement in the planning and execution of complex client‑facing programs, including end‑to‑end CDMO projects involving cell line development, linker‑payload, drug substance, drug product, and technical transfer activities as applicable.
• Identify and implement improvements to PMO effectiveness, including governance, reporting, prioritization, resource planning, and organizational capability.

• Serve as a senior PMO representative and trusted liaison for client stakeholders, ensuring strong communication, transparency, responsiveness, and alignment throughout the project lifecycle.
• Lead or participate in Joint Steering Committee (JSC) meetings and other governance forums with clients, providing clear updates on program status, risks, financials, scope changes, and milestones.
• Partner closely with Business Development, Development, and Operations to support new business opportunities, project…