Process Development Engineer II, Analytics: Synthetic and Bioconjugation Scale-Up Technologies; SBST

Position: Process Development Engineer II, Analytics: Synthetic and Bioconjugation Scale-Up Technologies (SBST)
Regeneron's Preclinical Manufacturing & Process Development (PMPD) organization in Tarrytown, NY is seeking a highly motivated Process Development Engineer II to join our Synthetic and Bioconjugation Scale-up Technologies (SBST) Analytics group. In this role, you will serve as the analytical lead to develop fit-for-purpose analytical methods to characterize critical intermediates (small molecules, siRNA, and/or peptides) to support our growing and diverse bioconjugate pipeline.

You will lead and implement analytical deliverables working closely with cross-functional teams and external collaborators (CDMOs) to advance bioconjugate programs from development to commercialization.

A Typical Day in the Role of Process Development Engineer II Might Look Like:

* Design and execute analytical testing, method development and characterization of critical intermediates to enable bioconjugate development.

* Compile, analyze, and interpret complex datasets; connect key findings across experiments and propose clear, actionable next steps.

* Communicate results and recommendations clearly to technical and non-technical audiences to enable timely, data-driven decisions.

* Serve as the analytical lead for critical intermediates and bioconjugates; coordinate internal and external analytical deliverables (development, transfer, and troubleshooting) to support program milestones.

* Provide technical support and troubleshooting to receiving labs to keep analytical activities off the critical path.

* Author high-quality documentation (e.g., procedures, method development reports, characterization reports, ELN entries) to support program timelines.

* Build and improve business workflows for documentation standardization, data digitization, and sample management.

* Maintain compliance with lab and environmental safety and promote a safe lab culture.

* Support equipment upkeep, troubleshooting, maintain an organized workspace, and proactively plan for lab resources.

* Train and mentor peers and junior team members as needed (directly and/or indirectly).

This Role May Be For You If You:

* Enjoy hands-on lab work and consistently generate high-quality, reproducible data.

* Take initiative, deliver on challenging work, and learn new technologies quickly.

* Have hands-on experience with analytical techniques for synthetic molecules (i.e., peptide, siRNA, and small-molecule) characterization and relevant software's.

* Possess a customer-centric mindset to analytical development and understand how analytical deliverables enable program decisions across drug development in different phases of the program

* Thrive in a fast-paced, highly collaborative environment working on complex problems.

* Communicate clearly (written and verbal), simplify messages for impact, and build strong working relationships.

* Think critically and apply strong problem-solving skills, and comfortable navigating ambiguity.

This role requires B.S. with 6+ years of relevant experience, or M.S. with 4+ years of relevant experience, in analytical chemistry, biochemistry, biology, chemical engineering, or a related field. Hands-on experience with analytical method development for synthetic molecules (e.g., small molecules, PEG, peptides, and/or oligos), i.e. electrophoresis, HPLC, MS, UV spectroscopy and associated software (e.g., Empower). Experience transferring methods to internal/external development labs, and troubleshooting.

Demonstrated experience serving as an analytical lead, working with internal teams and external CDMOs. Strong written and verbal communication skills, including the ability to present data clearly to diverse audiences. Ability to work with minimal guidance and collaboratively across cross-functional teams, with strong attention to detail and documentation practices. Demonstrated initiative, learning agility, and a growth mindset in a fast-paced environment.

Experience with antibodies and/or bioconjugates is strongly preferred.

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