Associate Scientist

Associate Scientist – Mass Spectrometry (LC-MS)

This Associate Scientist role offers the opportunity to work in an innovative mass spectrometry laboratory, executing LC-MS methods to characterize biotherapeutic products across all stages of drug development, from early-stage candidate selection through late-stage regulatory submissions. You will perform routine and advanced analytical tasks to support a diverse R&D pipeline, focusing on protein and modality characterization, and will collaborate closely with cross-functional teams to solve complex drug development challenges.

Responsibilities

• Execute established LC-MS-based analytical protocols to characterize biotherapeutic products, including monoclonal antibodies, bispecific antibodies, Fc-fusion proteins, adeno-associated virus (AAV), siRNA, and other emerging modalities.
• Perform detailed LC-MS characterization activities to elucidate protein structures, post-translational modifications, sequence variants, and glycan profiles that support all phases of drug development.
• Provide analytical support to cross-functional teams such as formulation development, upstream and downstream process development, and manufacturing, contributing data and insights to address drug development challenges.
• Independently conduct sample preparation for LC-MS analyses, ensuring compliance with standard operating procedures (SOPs) and best practices for analytical chemistry and protein chemistry.
• Operate LC-MS instrumentation and associated liquid chromatography systems to generate high-quality, reproducible analytical data.
• Document experimental procedures, data, and interpretations accurately and comprehensively in an electronic laboratory notebook (ELN).
• Manage, organize, and visualize analytical data using appropriate software tools, ensuring data integrity and traceability.
• Plan and prioritize daily and weekly laboratory work using strong organizational and time-management skills to meet project timelines and deliverables.
• Communicate experimental progress, results, and conclusions clearly and in a timely manner to project teams and stakeholders, both verbally and in written reports.
• Support the maintenance of a safe, compliant, and well-organized laboratory environment, including adherence to SOPs and relevant laboratory standards.
• Contribute to continuous improvement of analytical methods and workflows by sharing observations, troubleshooting issues, and collaborating with colleagues in the analytical development team.

Essential Skills

• Bachelor's or Master's degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related scientific field.
• 0–2 years of industry experience, ideally in a biotechnology or pharmaceutical environment.
• Foundational knowledge of chemistry and protein chemistry, including principles relevant to biotherapeutic characterization.
• Hands-on experience with liquid chromatography (LC) techniques, particularly in the context of protein and peptide analysis.
• Basic experience or strong academic exposure to LC-MS methods and their application to protein or biotherapeutic analysis.
• Ability to follow and execute established laboratory protocols and standard operating procedures with high attention to detail.
• Proficiency in documenting experiments, procedures, and results accurately in an electronic laboratory notebook (ELN) or similar system.
• Strong organizational skills with the ability to plan, prioritize, and manage multiple tasks in a fast-paced R&D environment.
• Effective written and verbal communication skills to deliver clear, timely updates and present analytical findings to project teams.
• Demonstrated ability to work independently at the bench while collaborating effectively within a team-focused environment.

Additional Skills & Qualifications

• Industry experience in a biotech or pharmaceutical setting supporting drug development programs is highly desirable.
• Familiarity with advanced mass spectrometers such as Q Exactive Plus, Exploris, or similar high-resolution instruments.
• Experience with or exposure to liquid-handling systems and automated liquid-handling platforms (e.g., Bravo) for sample preparation.
• Working knowledge of data…