Associate Scientist - Therapeutic Proteins - Antibody Radioconjugates Technology

Build our future together:

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a highly motivated, detail-oriented, and dependable Associate Scientist to join Therapeutic Proteins - Antibody Radio conjugates Technology, conjugating antibodies with bifunctional chelates and fluorescent probes, and radiolabeling conjugated antibodies to support preclinical immunoPET (iPET) and Cryo-fluorescence Tomography (CFT) imaging. You'll generate and characterize Zr-89 radio labeled and fluorescently-conjugated tracers from our portfolio of antibodies and antibody-based therapeutics, enabling quantitative in vivo imaging studies across Oncology, Immuno-Oncology, and other therapeutic focus areas.

Your work will directly enable same-day imaging studies that visualize biodistribution, tumor/tissue targeting, and pharmacokinetics of therapeutic candidates in preclinical models.

When & where:

Location:

Tarrytown, NY - On-site

Discover your role:

* Performs bioconjugation of antibodies with bifunctional chelating agents (DFO, DOTA, etc.) and fluorescent probes following validated protocols

* Characterizes antibody bioconjugates using SE-HPLC, SDS-PAGE, Western blot, and UV/Vis spectroscopy

* Radiolabels bioconjugated antibodies with Zr-89, Cu-64, or other radionuclide isotopes; purifies radio labeled products for same-day use in time-critical imaging studies

* Runs quality control testing using radio-HPLC, radio-iTLC, and gamma counting to verify tracer quality before release

* Maintains mammalian cell culture lines and performs cell-based assays to validate tracer binding and function

* Coordinates tracer preparation timelines with imaging scientists and project teams across multiple therapeutic areas

* Maintains detailed electronic laboratory notebooks and radiation safety records in compliance with regulations

* Maintains instruments, troubleshoots instrumental/experimental problems, and orders/maintains supplies

This job might be for you if you:

* Have hands-on experience with protein chemistry, bioconjugation, and chromatographic techniques; experience performing radiochemistry is a plus

* Thrive in a collaborative, fast-paced environment where reliability and punctuality directly impact team success

* Take pride in maintaining accurate, complete laboratory records

* Excel at attention to detail and following established protocols with precision

* Are self-motivated and eager to work independently after training

* Have strong communication skills

This role requires:

* B.S. in Chemistry, Biochemistry, Chemical Engineering, Chemical Biology, or a related field with 1-2 years of laboratory experience

* Comfort working with radioactive materials and willingness to complete radiation safety training

* Hands-on experience with protein chemistry and bioconjugation techniques, or strong foundational knowledge with willingness to learn

* Experience with chromatographic techniques (HPLC, FPLC, or column chromatography) and mammalian cell culture

* Proficiency with computers, data analysis software (Excel, Prism, or similar), and electronic laboratory notebook systems

* Ability to lift 50 lbs

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.

Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for…