Scientist, Product Biochemistry

Scientist

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Scientist to join our Product Biochemistry team, on-site in Tarrytown, NY. In this role, you will support late-stage development (Phase II through commercialization) of biologics, developing and deploying analytical methods and purification strategies, enriching and characterizing product variants, and helping onboard new technologies that deepen product understanding and improve processes across the pipeline.

This position offers the opportunity to bring scientific creativity, efficiency, and flexibility to a fast-paced, science-driven organization making a meaningful difference to patients worldwide.

• Shift Requirements:
  Full-time, standard business hours
• Location:
  
  On-site in Tarrytown, NY
• Flexibility & travel:
  Minimal to no travel; on-site presence required to support laboratory operations

• Develop analytical methods and purification protocols to support extended characterization of therapeutic proteins and gene therapy vectors
• Conduct biochemical/biophysical characterization to support development, regulatory submissions, and commercialization
• Apply DOE, advanced statistics, and risk assessments to evaluate and optimize methods and processes
• Design and execute experiments to enrich, purify, and characterize size/charge variants, complexes, and high-concentration formulations
• Independently operate U/HPLCs and AKTA FPLCs, and perform capillary-based electrophoresis
• Integrate learnings from internal data and external literature to make science-based study design recommendations
• Author high-quality technical documents (protocols, reports, memos), contribute to regulatory sections and publications, and ensure timely documentation of experiments in accordance with established SOPs and guidelines
• Document experiments, results, and findings in the electronic laboratory notebook, and present work at group and department meetings
• Maintain instruments, troubleshoot instrumental/experimental problems, order/maintain supplies, and improve lab/data workflows within your area of expertise

• This is a hands-on, on-site laboratory role requiring independent operation of specialized analytical instrumentation and the ability to manage multiple priorities in a fast-moving R&D environment.
• Flexibility to thrive in a fast-paced, team environment while also working independently across multiple projects, and to mentor others while contributing to a safe, efficient, and inclusive lab environment, is required.

• BS/MS in Biochemistry, Biophysics, Engineering, or a related field, with 8-10+ years of relevant industry experience
• Strong lab skills in protein separation, purification, and tangential flow filtration (TFF), and skills in protein/product identification using mass spectrometry
• Excellent oral and written communication skills and evidence of teamwork
• Strong initiative to complete tasks, learn new technologies, and demonstrate a commitment to continuous learning
• Ability to communicate clearly, transparently, and in a timely manner with key stakeholders

• Technical proficiency in automated FPLC and/or HPLC (SEC, IEX, affinity), electrophoresis (capillary or microchip, SDS-PAGE, western blots), spectroscopy, and light scattering
• Fundamental understanding of protein structure/function, mass spectrometry, and immunology/immunogenicity
• Experience working in the biopharmaceutical industry

• Student Loan Paydown program & Tuition Reimbursement
• Family Care Benefits
• Relocation Assistance
• Inclusion, Culture and Well-Being programs (including physical & mental health)