Senior Manager, Portfolio Analytics & Strategy

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role you will lead portfolio analysis, performance tracking, and benchmarking, while owning Amgen’s Probability of Technical and Regulatory Success (PTRS) process across the R&D portfolio.

You will serve as a strategic thought partner to Product Teams, Therapeutic Area and Portfolio Governance, translating development risks, evidence, and uncertainty into decision-ready options. You will also oversee technology initiatives that enable PTRS and broader portfolio decision support, working closely with the Technology, Research, and Development organizations, Product Teams, and other cross-functional partners

• Lead and facilitate the enterprise PTRS assessment process with Product Teams and cross-functional experts at key development, investment, and governance milestones.
• Own and continuously evolve the PTRS methodology, standards, benchmarks, guardrails, governance cadence, and documentation, including integration with portfolio and business-case processes.
• Oversee development of new PTRS and risk‑assessment tools with the Technology organization and functional experts, including data products, evidence workflows, dashboards, and decision‑support capabilities.

• Partner with Product Teams to assess risk across alternative target product profiles, indication and population choices, biomarker strategies, and clinical development options.
• Facilitate evidence‑based discussions that distinguish established evidence from key assumptions, clarify what would confirm, challenge, or disconfirm the current risk posture, and help teams articulate trade‑offs across risk, value, timing, cost, and resource demand.

• Support portfolio reviews, prioritization, and investment decisions by assessing portfolio‑level trade‑offs across risk, value, timing, cost, and resources and developing clear options for Governance and senior leaders.
• Lead cross‑functional portfolio performance tracking and industry benchmark participation across cycle times, success rates, portfolio composition, productivity, throughput, and other development KPIs to identify trends, gaps, and improvement opportunities.

• Deliver decision‑ready insights on portfolio risk, value, performance, and key trade‑offs for Product Teams, Governance, and senior leadership. Maintain consistency across PTRS, valuation, planning, and governance assumptions, and use historical outcomes, internal performance trends, and external benchmarks to calibrate assessments and improve decision quality over time.

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is dynamic, goal oriented and results driven with these qualifications:

Doctorate degree and 2 years of experience in R&D portfolio…