Senior Manufacturing Systems Engineer Manufacturing Systems and Integrated Technologies
Listed on 2026-06-02
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Engineering
Systems Engineer, Cybersecurity
Senior Manufacturing Systems Engineer – Manufacturing Systems and Integrated Technologies
What You Will Do
In this vital role, you will be part of our Clinical and Commercial Manufacturing Operations Technology team. You will drive the operation, refinement, and integration of cutting‑edge manufacturing applications. This role is an excellent opportunity to gain an understanding of Amgen’s key manufacturing systems, working with various MCS (Manufacturing and Clinical Supply) business partners to ensure products reach patients by managing and supporting key computerized systems such as MES (Manufacturing Execution System), Clinical Label Printing and Packaging, PI Data Historian, Instrument Data Acquisition (IDA) and other integrated systems.
As a member of our team, you'll be the driving force behind our mission to deliver high‑quality products efficiently and effectively. You will manage the MES platform and associated integrations for the ATO site, support the Global Instrument Data Acquisition (IDA) team, and drive a Global MES Standardization effort across all Amgen manufacturing locations. Your work will optimize manufacturing systems, enhance data integrity, and promote consistency and efficiency across Amgen’s worldwide network.
You will collaborate closely with cross‑functional teams, site business leads, and plant leads (Manufacturing, Supply Chain, Quality, MCS Engineering, Enterprise Architects, MES/IDA Global Teams) to ensure seamless implementation and optimization of MES, PI Historian Systems, and support partners with MCS automation/engineering teams for GLAM project support. The role is part of the Site Operations Technology team responsible for delivering systems in support of Clinical and Commercial Manufacturing, working in a client‑facing ATO site‑focused approach.
Responsibilities- Support key TCT manufacturing systems by driving operational stability and continuous improvements across Building 7, B20, B23, and the ATO site.
- Manage key system integrations, both existing and new, to streamline manufacturing operations.
- Champion business process improvements and support strategic digital initiatives by leveraging established platforms, city plan technology, and artificial intelligence applications.
- Provide on‑call support, including after‑hours escalations and troubleshooting for operations technology application issues, aligned with 24×7 manufacturing requirements at the ATO site.
- Lead major incident and problem investigations, including root cause analysis, deviation investigations, corrective actions, and 5‑why analysis.
- Ensure compliance by maintaining and updating inspection readiness for critical applications, including inspection playbooks, periodic assessments for data integrity, security, and system compliance, and SDLC validation and testing.
- Support regulatory inspections by providing data, delivering presentations on site systems and technology processes, and collaborating with subject‑matter experts as needed.
- Lead initiatives to introduce Industry 4.0 technologies to improve manufacturing efficiency and capacity.
- Lead and train team members to support operational excellence and develop multi‑system competencies.
- Support and lead CMDB updates and system health, ensuring accurate and up‑to‑date configuration data in partnership with service owners and managers.
- Support the assessment of impactful changes during weekly ATO Change Advisory Board (CAB) meetings.
- Support Amgen’s cyber resiliency efforts, including Sentinels and ECR Network initiatives.
- Provide on‑site, client‑facing support at the ATO site up to five days per week, based on business needs.
We are all different, yet we all use our unique contributions to serve patients. The professional we seek is an individual with these qualifications.
Basic Qualifications- Doctorate degree
- or Masters degree and 2 years of Information Systems/Systems Engineering experience
- or Bachelors degree and 4 years of Information Systems/Systems Engineering experience
- or Associates degree and 8 years of Information Systems/Systems Engineering experience
- or High school diploma / GED and 10 years of Information Systems/Systems…
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