Development & Manufacturing Senior Manager

Position: Contract Development & Manufacturing Senior Manager
Career Category

Manufacturing

Job Description

Join Amgen's Mission of Serving Patients

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas
-Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Contract Development & Manufacturing Senior Manager

What you will do

Let's do this. Let's change the world. In this vital role, you will provide strategic and operational leadership within Amgen Contract Development and Manufacturing (ACDM), driving execution of external development and manufacturing activities for Synthetic Drug Substance (DS) programs supporting Antibody Drug Conjugate (ADC) and Small Molecule modalities across clinical and commercial stages.

This role is responsible for leading complex, cross-functional programs with external development and manufacturing partners (CDMOs/CROs) to ensure reliable, compliant, and efficient supply execution. The successful candidate will demonstrate strong leadership capabilities, technical breadth across synthetic modalities, and the ability to influence internal and external stakeholders in a dynamic global environment. This position sits within External Supply in Operations and plays a critical role in enabling Amgen's external sourcing and manufacturing strategy across the portfolio.

In alignment with evolving business needs, this role may also support additional hybrid or emerging modalities.

Key Responsibilities

* Lead external Synthetic DS programs for ADC and Small Molecule modalities across development, clinical, and commercial stages.

* Serve as the primary interface with CDMOs/CROs and internal cross-functional teams including Process Development, Quality, Supply Chain, Analytical, Regulatory, and Strategic Sourcing.

* Drive sourcing activities including supplier selection, onboarding, scope of work development, and proposal management.

* Oversee manufacturing operations, technical transfers, compliance, and issue resolution with external partners.

* Ensure project delivery against quality, compliance, supply, timeline, and cost objectives.

* Lead risk management, escalation resolution, and operational decision-making across programs.

* Build strong internal and external partnerships to support program success and operational excellence.

* Influence and lead matrix teams in a fast-paced, complex environment.

* Manage quality systems activities including deviations, investigations, change controls, and CAPAs.

* Manage budgets, purchase orders, and financial forecasting for external manufacturing activities.

* Drive continuous improvement, process optimization, and operational excellence initiatives.

* Support supplier management and contract-related activities.

* Mentor and train ACDM staff and cross-functional teams and demonstrate strong leadership, collaboration, and accountability.

* Support additional hybrid or emerging modalities based on business needs.

* Travel up to 20%, including domestic and international travel.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dedicated professional we seek is a collaborative partner with these qualifications.

Basic Qualifications:

* Doctorate degree and 2 years of Manufacturing, Operations, Process Development, or External Supply experience OR

* Master's degree and 4 years of Manufacturing, Operations, Process Development, or External Supply experience OR

* Bachelor's degree and 6 years of Manufacturing, Operations, Process Development, or External Supply experience OR

* Associate's degree and 10 years of Manufacturing, Operations, Process Development, or External Supply experience OR

* High school diploma / GED and 12 years of Manufacturing, Operations, Process Development, or External Supply experience

Preferred Qualifications:

* Advanced degree in Chemistry, Chemical Engineering, Pharmaceutical Sciences, or related field preferred.

* 10+ years of pharmaceutical or biotechnology experience in Synthetic DS development and manufacturing.

* Experience supporting Small Molecule and/or ADC modalities from development through commercial…