Synthetics Supply Manufacturing Engineer

Synthetics Supply Manufacturing Engineer

Amgen is seeking a Synthetic Supply Manufacturing Engineer to join our Drug Substance and Drug Product facilities in Thousand Oaks. The role focuses on the execution of small molecule active pharmaceutical ingredient (API) production and the development of clinical formulations for solid oral drug product dosage forms.

• Lead reaction step scale‑up in up to 100 L reactor trains under the supervision of the Lab Manager.
• Perform equipment maintenance and cleaning.
• Qualify equipment.
• Create batch records for GLP/GMP campaigns.
• Manage manufacturing timelines.
• Support other operational needs of the facility.
• Collaborate with process development chemists, formulation scientists, engineers, analysts, EH&S, Quality, F&E, maintenance, and other supporting functions.

• Master’s degree.
• OR Bachelor’s degree and 2 years of engineering experience.
• OR Associate’s degree and 6 years of engineering experience.
• OR High school diploma / GED and 8 years of engineering experience.

• BS or MS in Chemical Engineering.
• Alternatively, life science or related field with 5 years of relevant experience.
• Previous industrial hands‑on experience in a GMP chemical manufacturing environment.
• Strong familiarity with safe chemical handling techniques including weighing, dispensing, and packaging of chemicals, drug substance intermediates, and APIs.
• In‑depth understanding of unit operations for the manufacture of synthetic drug products (granulation, roller compaction, drying, milling, blending, compression, encapsulation, and film coating).
• Ability to perform preventive maintenance and troubleshoot manufacturing equipment.
• PPE familiarity and ability to use a chemical respirator.
• Experience with laboratory automation including temperature control and data logging platforms such as Delta V.
• Excellent verbal and written communication skills.
• Proficiency with Microsoft Word, Excel, and PowerPoint.
• Advanced scientific/technical reading and writing skills, advanced scientific analysis skills, and ability to collaborate in a team environment.
• Strong familiarity with Good Documentation Practices.
• Strong interpersonal skills and a proactive leadership mindset.
• Ability to work independently, as part of a team, self‑motivation, adaptability, and a positive attitude.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors, including but not limited to relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan that includes health and welfare plans for staff and eligible dependents, financial plans, work‑life balance, and career development opportunities.

Benefits also include a comprehensive employee benefits package (retirement and savings plan, group medical, dental and vision coverage, life and disability insurance, flexible spending accounts), a discretionary annual bonus program, stock‑based long‑term incentives, award‑winning time‑off plans, and flexible work models where possible.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Please contact us to request accommodation.