Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs

Overview

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer biotech in our fight against the world’s toughest diseases. Amgen focuses on Oncology, Inflammation, General Medicine, and Rare Disease, reaching millions of patients each year.

We are advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a team member, you’ll help make a lasting impact on patients’ lives as we research, manufacture, and deliver innovative medicines.

Our award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities within them, you’ll thrive as part of the Amgen team.

Process Development Senior Scientist
- Synthetic Peptides, Oligonucleotides, ADCs

Let’s do this. Let’s change the world. In this vital role you will join our Drug Substance Technologies
- Synthetics (DSTS) group at our Thousand Oaks campus. Amgen’s DSTS group within Process Development (PD) is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance Amgen's portfolio of synthetic and hybrid assets. Process chemists apply their synthetic training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late-stage development.

The role includes developing innovative solutions to support chemical and bio-conjugation process development of hybrid modality drug candidates, including antibody drug conjugates, peptide antibody conjugates, synthetic peptides, and/or oligonucleotides. The successful candidate will provide technical expertise and translate developed processes toward manufacturing and commercialization. The candidate will be highly motivated, team-oriented, with a strong background in organic chemistry and/or bioconjugation chemistry and a track record of scientific innovation.

• Work effectively with a diverse team of synthetic chemists, chemical engineers, and analytical chemists to invent synthetic routes and develop safe, robust, sustainable, and cost-effective processes for antibody drug conjugate, peptide antibody conjugates, synthetic peptides and/or oligonucleotide manufacturing
• Drive technology innovation in the synthesis, purification, and characterization of bioconjugates, oligonucleotides, and/or synthetic peptides
• Support cGMP manufacturing and technology transfer to internal manufacturing facilities and external contract manufacturers
• Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency
• Ensure process performance through process understanding, modeling, and characterization
• Contribute to drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, and recommendations
• Work cross-functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and stay current in bioconjugation, antibody drug conjugates, oligonucleotides, peptides, and process chemistry and manufacturing
• Work independently in advancing projects and studies within required deadlines

We are all different, yet we all use our unique contributions to serve patients. The scientific professional we seek is an individual with these qualifications.

• Doctorate degree (PhD OR PharmD OR MD) and relevant post-doc where applicable
• OR
• Master’s degree and 3 years of scientific experience
• OR
• Bachelor’s degree and 5 years of scientific experience

• Ph.D. in organic chemistry, chemical biology or biochemistry with expertise in antibody drug conjugate, synthetic oligonucleotide, and/or synthetic peptide process development
• Post-doctoral experience in an academic laboratory or pharmaceutical/biotech industry
• Extensive hands-on expertise in the…